Recent advances in genomics and therapeutics in mantle cell lymphoma

T Lu, J Zhang, JM McCracken, KH Young - Cancer Treatment Reviews, 2023 - Elsevier
Over the past decades, significant strides have been made in understanding the
pathobiology, prognosis, and treatment options for mantle cell lymphoma (MCL). The …

Biological and Clinical Determinants Shaping Heterogeneity in Mantle Cell Lymphoma

C López, E Silkenstedt, M Dreyling, S Beà - Blood Advances, 2024 - Elsevier
Mantle cell lymphoma (MCL) is an uncommon mature B cell lymphoma which presents a
clinical spectrum ranging from indolent to aggressive disease, with challenges in disease …

Prognostic value of CDKN2A in head and neck squamous cell carcinoma via pathomics and machine learning

Y Wang, C Zhou, T Li, J Luo - Journal of Cellular and Molecular …, 2024 - Wiley Online Library
This study aims to enhance the prognosis prediction of Head and Neck Squamous Cell
Carcinoma (HNSCC) by employing artificial intelligence (AI) to analyse CDKN2A gene …

Unraveling MCL biology to understand resistance and identify vulnerabilities

C Sarkozy, B Tessoulin, D Chiron - Blood, 2024 - Elsevier
Mantle cell lymphoma (MCL) is a rare (5-7%), aggressive B-cell non-Hodgkin's lymphoma
with well-defined hallmarks (eg Cyclin D1, SOX11), and whose expansion is highly …

Impact of PIK3CA gain and PTEN loss on mantle cell lymphoma biology and sensitivity to targeted therapies

N Bettazova, J Senavova, K Kupcova, D Sovilj… - bioRxiv, 2024 - biorxiv.org
Besides many other mutations in known cancer driver genes, mantle cell lymphoma (MCL)
is characterized by recurrent genetic alterations of important regulators of the …