Regeneration is the process of replacing/restoring a damaged cell/tissue/organ to its full
function and is limited respecting complexity of specific organ structures and the level of …

We provide a comprehensive classification of the proteoglycan gene families and respective
protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular …

Sulfation is a dynamic and complex posttranslational modification process. It can occur at
various positions within the glycosaminoglycan (GAG) backbone and modulates …

An astonishing number of extracellular matrix glycoproteins are expressed in dynamic
patterns in the developing and adult nervous system. Neural stem cells, neurons, and glia …

Chondroitin sulfate proteoglycans (CSPGs) consist of a core protein and glycosaminoglycan
(GAG) chains. There is enormous structural diversity among CSPGs due to variation in the …

Proteoglycans are associated with all kinds of amyloid deposits in the human body. These
complex macromolecules, in particular heparan sulphate proteoglycans, have also been …

Neuronal differentiation is a fundamental event in the development of the nervous system as
well as in the regeneration of damaged nervous tissue. The initiation and guidance of a …

Two major types of glycosaminoglycan (GAG) polysaccharides, heparan sulfate and
chondroitin sulfate, are polymerized and modified by enzymes that are encoded by more …

CNS damage often results in demyelination of spared axons due to oligodendroglial cell
death and dysfunction near the injury site. Although new oligodendroglia are generated …

Human interfollicular epidermis is renewed by stem cells that are clustered in the basal layer
in a patterned, non-random distribution. Stem cells can be distinguished from other …