Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan
(CSPG)-containing structures that surround the soma and dendrites of various mammalian …

All components of the CNS are surrounded by a diffuse extracellular matrix (ECM)
containing chondroitin sulphate proteoglycans (CSPGs), heparan sulphate proteoglycans …

Activation of microglia in the spinal cord dorsal horn after peripheral nerve injury contributes
to the development of pain hypersensitivity. How activated microglia selectively enhance the …

Astrocytes sense changes in neural activity and extracellular space composition. In
response, they exert homeostatic mechanisms critical for maintaining neural circuit function …

All cells sense and integrate mechanical and biochemical cues from their environment to
orchestrate organismal development and maintain tissue homeostasis …

Remyelination failure contributes to axonal loss and progression of disability in multiple
sclerosis. The failed repair process could be due to ongoing toxic neuroinflammation and to …

Extracellular matrix (ECM) molecules in the central nervous system form highly organized
ECM structures around cell somata, axon initial segments, and synapses and play …

During restricted time windows of postnatal life, called critical periods, neural circuits are
highly plastic and are shaped by environmental stimuli. In several mammalian brain areas …

Memory, defined as the storage and use of learned information in the brain, is necessary to
modulate behavior and critical for animals to adapt to their environments and survive …

Chondroitin sulphate proteoglycans in the extracellular matrix restrict plasticity in the adult
central nervous system and their digestion with chondroitinase reactivates plasticity …