Peptides released in the spinal cord from the central terminals of nociceptors contribute to
the persistent hyperalgesia that defines the clinical experience of chronic pain. Using …

Loss-of-function mutations in the genes encoding either neurokinin B (NKB) or its receptor,
NK3 (NK3R), result in hypogonadotropic hypogonadism, characterized by an absence of …

The involvement of neurokinin receptors in visceral nociception is well documented.
However, the role and localization of NK3 receptors is not clearly established. This study …

The effects of the NK3 tachykinin receptor antagonist SR 142801 on synaptic transmission
and spike windup induced by trains of stimuli applied to a dorsal root were investigated with …

Intracellular recording from lumbar motoneurons and extracellular recording from ventral
roots of the neonatal rat isolated spinal cord were used to study the mechanisms …

This study was designed to provide evidence for elucidating the mechanisms of neurokinin‐
3 receptor (NK3) in spinal pain modulation. First, colocalization of NK3 with the µ‐opioid …

Sensory processing in the spinal cord involves interactions among primary afferent fibers
bearing information from sensory receptors, interneurons, ascending tract cells conveying …

The neurokinin receptors NK1 and NK3 are involved in processing nociceptive information
in the spinal dorsal horn and in central changes following persistent peripheral injury …

Hypothalamic input is vital to the regulation of reproductive function. Gonadotropin-releasing
hormone (GnRH) is secreted by hypothalamic GnRH neurons into the hypophysial portal …

Approximately 75% of menopausal women in the United States experience hot flushes but
the etiology of this thermoregulatory disorder is unknown. The dominant theory is that …