A review of Glycogen Synthase Kinase-3 (GSK3) inhibitors for cancers therapies

R Thapa, G Gupta, AA Bhat, WH Almalki… - International journal of …, 2023 - Elsevier
The intricate molecular pathways governing cancer development and progression have
spurred intensive investigations into novel therapeutic targets. Glycogen Synthase Kinase-3 …

A comprehensive review on the emerging role of long non-coding RNAs in the regulation of NF-κB signaling in inflammatory lung diseases

AA Bhat, O Afzal, N Agrawal, R Thapa… - International journal of …, 2023 - Elsevier
Public health globally faces significant risks from conditions like acute respiratory distress
syndrome (ARDS), chronic obstructive pulmonary disease (COPD), and various …

The pyroptotic role of Caspase-3/GSDME signalling pathway among various cancer: A Review

AA Bhat, R Thapa, O Afzal, N Agrawal… - International journal of …, 2023 - Elsevier
Cytotoxic drugs have long been recognised to kill cancer cells through apoptosis. According
to a current study, pyroptosis inhibits cell proliferation and shrinks tumors. Pyroptosis and …

Unlocking the potential of mesoporous silica nanoparticles in breast cancer treatment

R Thapa, H Ali, O Afzal, AA Bhat, WH Almalki… - Journal of Nanoparticle …, 2023 - Springer
Breast cancer is the most common cancer among women and is typically managed through
surgery, radiation therapy, and chemotherapy. However, chemotherapy drugs often lack …

MALAT1: A key regulator in lung cancer pathogenesis and therapeutic targeting

AA Bhat, O Afzal, M Afzal, G Gupta, R Thapa… - … -Research and Practice, 2023 - Elsevier
Lung cancer remains a formidable global health burden, necessitating a comprehensive
understanding of the underlying molecular mechanisms driving its progression. Recently …

Unwinding circular RNA's role in inflammatory pulmonary diseases

AA Bhat, G Gupta, A Goyal, R Thapa… - Naunyn-Schmiedeberg's …, 2024 - Springer
Circular RNAs (circRNAs) have emerged as pivotal regulators of gene expression and
cellular processes in various physiological and pathological conditions. In recent years …

New horizons in lung cancer management through ATR/CHK1 pathway modulation

R Thapa, O Afzal, AA Bhat, A Goyal… - Future medicinal …, 2023 - Taylor & Francis
Lung cancer is the leading cause of cancer-related deaths worldwide. Molecular profiling
has contributed to a new classification of lung cancer, driving advancements in research and …

From LncRNA to metastasis: The MALAT1-EMT axis in cancer progression

R Thapa, O Afzal, M Afzal, G Gupta, AA Bhat… - … -Research and Practice, 2023 - Elsevier
Cancer is a complex disease that causes abnormal genetic changes and unchecked cellular
growth. It also causes a disruption in the normal regulatory processes that leads to the …

From carcinogenesis to therapeutic avenues: lncRNAs and mTOR crosstalk in lung cancer

MS Hussain, ASA Altamimi, M Afzal, I Kazmi… - … -Research and Practice, 2023 - Elsevier
Long non-coding RNAs (lncRNAs) have been demonstrated to have a crucial function in the
modulation of the activity of genes, impacting a variety of homeostatic processes involving …

PVT1 lncRNA in lung cancer: A key player in tumorigenesis and therapeutic opportunities

MA Hakami, A Hazazi, FR Khan, O Abdulaziz… - … -Research and Practice, 2023 - Elsevier
The lncRNA PVT1 has emerged as a pivotal component in the intricate landscape of cancer
pathogenesis, particularly in lung cancer. PVT1, situated in the 8q24 chromosomal region …