purpose. The PITX3 gene, which codes for a homeobox bicoidlike transcription factor is
responsible for dominant cataract and anterior segment mesenchymal dysgenesis in …

Objective To identify orodental characteristics and genetic aetiology of a family affected with
non‐syndromic orodental anomalies. Subjects and Methods Physical and oral features were …

Pitx2, a bicoid-related homeobox gene, plays a crucial role in the left-right axis
determination and dextral looping of the vertebrate developing heart. We have examined the …

We are taking a cross-species approach to identify genes that are required for mammalian
GABAergic neuron differentiation. On the basis of homeodomain similarity, the vertebrate …

Oncogenic multidrug resistance (MDR) is a multifactorial phenotype intimately linked to
deregulated expression of detoxification transporters. Drug efflux transporters, particularly …

Aristaless-related homeobox gene (ARX) is an important paired-type homeobox gene
involved in the development of human brain. The ARX gene mutations are a significant …

We aimed to characterize the genetic basis and craniofacial and dental features of Finnish
patients with Axenfeld‐Rieger syndrome (ARS). Mutational analyses of seven patients in five …

Pitx2, Wnt/β-catenin signaling, and microRNAs (miRs) play a critical role in the regulation of
dental stem cells during embryonic development. In this report, we have identified a Pitx2: β …

PITX2 and Nkx2. 5 are two of the earliest known transcriptional markers of vertebrate heart
development. Pitx2–/–mice present with severe cardiac malformations and embryonic …

In this study, we extend our examination of the function of the Prrx1 (aka Mhox, Prx1, K-2,
and Pmx1) as well as Prrx2 (aka S8 and Prx2) genes by characterizing the expression of the …