GAD67 corresponds to one of two enzymes that decarboxylates glutamate to produce γ-
aminobutyric acid, the main inhibitory neurotransmitter in the mammalian central nervous …

Background Congenital cataracts are clinically and genetically heterogeneous with more
than 45 known loci and 38 identified genes. They can occur as isolated defects or in …

Homeodomain (HD) transcriptional activities are tightly regulated during embryogenesis and
require protein interactions for their spatial and temporal activation. The chromatin …

Purpose Axenfeld-Rieger syndrome is a genetically heterogenous, autosomal dominant
disorder that is characterized by anterior segment defects, glaucoma, and extraocular …

The non-canonical Wnt pathway, a regulator of cellular motility and morphology, is
increasingly implicated in cancer metastasis. In a quantitative PCR array analysis of 84 Wnt …

Wolf-Hirschhorn syndrome (WHS) is a developmental disorder attributed to a partial deletion
on the short arm of chromosome 4. WHS patients suffer from oral manifestations including …

Microphthalmia is a severe ocular disorder, and this condition is typically caused by
mutations in transcription factors that are involved in eye development. Mice carrying …

FoxJ1 is a forkhead transcription factor expressed in multiple tissues during development
and a major regulator of cilia development. FoxJ1−/− mice present with defects in …

Craniofacial morphogenesis is driven by spatial–temporal terrains of gene expression,
which give rise to stereotypical pattern formation. Transcription factors are key cellular …

Paired-like homeodomain transcription factors (PITX) regulate the activity of pituitary
hormone-encoding genes. Here, we examined mechanisms through which the family of …