Autophagic pathways cross with lipid homeostasis and thus provide energy and essential
building blocks that are indispensable for liver functions. Energy deficiencies are …

Evolutionarily conserved across eukaryotic cells, macroautophagy (herein autophagy) is an
intracellular catabolic degradative process targeting damaged and superfluous cellular …

Mitochondrial quality control is critical for cardiac homeostasis as these organelles are
responsible for generating most of the energy needed to sustain contraction. Dysfunctional …

Macroautophagy is a conserved catabolic process observed in all eukaryotic cells, during
which selected cellular components are transported to and broken down within lysosomes …

Macroautophagy involves the sequestration of cytoplasmic contents in a double-membrane
autophagosome and their delivery to lysosomes for degradation. In multicellular organisms …

The eukaryotic endomembrane system consists of multiple interconnected organelles. Rab
GTPases are organelle-specific markers that give identity to these membranes by recruiting …

Macroautophagy (autophagy) is a highly conserved intracellular degradation system that is
essential for homeostasis in eukaryotic cells. Due to the wide variety of the cytoplasmic …

Exosomes are vesicles secreted to the extracellular environment through fusion with the
plasma membrane of specific endosomes called multivesicular bodies (MVB) and mediate …

Over the past two decades, the molecular machinery that underlies autophagic responses
has been characterized with ever increasing precision in multiple model organisms …

Autophagy is a highly conserved self-degradative process that has a key role in cellular
stress responses and survival. Recent work has begun to explore the function of autophagy …