The ménage à trois of autophagy, lipid droplets and liver disease
Y Filali-Mouncef, C Hunter, F Roccio, S Zagkou… - Autophagy, 2022 - Taylor & Francis
Autophagic pathways cross with lipid homeostasis and thus provide energy and essential
building blocks that are indispensable for liver functions. Energy deficiencies are …
building blocks that are indispensable for liver functions. Energy deficiencies are …
Dual role of autophagy in hallmarks of cancer
Evolutionarily conserved across eukaryotic cells, macroautophagy (herein autophagy) is an
intracellular catabolic degradative process targeting damaged and superfluous cellular …
intracellular catabolic degradative process targeting damaged and superfluous cellular …
Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired
Mitochondrial quality control is critical for cardiac homeostasis as these organelles are
responsible for generating most of the energy needed to sustain contraction. Dysfunctional …
responsible for generating most of the energy needed to sustain contraction. Dysfunctional …
[HTML][HTML] Autophagosome-lysosome fusion
Macroautophagy is a conserved catabolic process observed in all eukaryotic cells, during
which selected cellular components are transported to and broken down within lysosomes …
which selected cellular components are transported to and broken down within lysosomes …
[HTML][HTML] Autophagosome maturation: an epic journey from the ER to lysosomes
YG Zhao, H Zhang - The Journal of cell biology, 2019 - ncbi.nlm.nih.gov
Macroautophagy involves the sequestration of cytoplasmic contents in a double-membrane
autophagosome and their delivery to lysosomes for degradation. In multicellular organisms …
autophagosome and their delivery to lysosomes for degradation. In multicellular organisms …
[HTML][HTML] Who's in control? Principles of Rab GTPase activation in endolysosomal membrane trafficking and beyond
AC Borchers, L Langemeyer… - The Journal of cell …, 2021 - ncbi.nlm.nih.gov
The eukaryotic endomembrane system consists of multiple interconnected organelles. Rab
GTPases are organelle-specific markers that give identity to these membranes by recruiting …
GTPases are organelle-specific markers that give identity to these membranes by recruiting …
New insights into autophagosome–lysosome fusion
S Nakamura, T Yoshimori - Journal of cell science, 2017 - journals.biologists.com
Macroautophagy (autophagy) is a highly conserved intracellular degradation system that is
essential for homeostasis in eukaryotic cells. Due to the wide variety of the cytoplasmic …
essential for homeostasis in eukaryotic cells. Due to the wide variety of the cytoplasmic …
ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins
Exosomes are vesicles secreted to the extracellular environment through fusion with the
plasma membrane of specific endosomes called multivesicular bodies (MVB) and mediate …
plasma membrane of specific endosomes called multivesicular bodies (MVB) and mediate …
Molecular definitions of autophagy and related processes
Over the past two decades, the molecular machinery that underlies autophagic responses
has been characterized with ever increasing precision in multiple model organisms …
has been characterized with ever increasing precision in multiple model organisms …
Autophagy in cancer metastasis
EE Mowers, MN Sharifi, KF Macleod - Oncogene, 2017 - nature.com
Autophagy is a highly conserved self-degradative process that has a key role in cellular
stress responses and survival. Recent work has begun to explore the function of autophagy …
stress responses and survival. Recent work has begun to explore the function of autophagy …