Hydraulic fracturing to extract oil and natural gas reserves is an increasing practice in many
international energy sectors. Hydraulic fracturing flowback and produced water (FPW) is a …

Abstract Intracellular calcium (Ca2+) alternans is a dynamical phenomenon in ventricular
myocytes, which is linked to the genesis of lethal arrhythmias. Iterated map models of …

We have previously shown that direct vagus nerve stimulation (VNS) reduces the slope of
action potential duration (APD) restitution while simultaneously protecting the heart against …

Cardiac alternans, defined as beat-to-beat alternations in action potential duration, cytosolic
Ca transient (CaT) amplitude, and cardiac contraction is associated with atrial fibrillation …

Optical mapping is widely used in experimental cardiology, as it allows visualization of
cardiac membrane potential and calcium transients. However, optical mapping …

The L-type Ca current (I Ca, L), essential for normal cardiac function, also regulates dynamic
action potential (AP) properties that promote ventricular fibrillation. Blocking I Ca, L can …

Background—Marked changes in ventricular APD restitution and associated alternans
rhythm have been demonstrated in structural heart disease (SHD). However, whether this is …

Rationale: Discordant alternans, a phenomenon in which the action potential duration
(APDs) and/or intracellular calcium transient durations (CaDs) in different spatial regions of …

Aims Hypertension is a major risk factor for atrial fibrillation. We hypothesized that arterial
hypertension would alter atrial myocyte calcium (Ca2+) handling and that these alterations …

Background—Apamin-sensitive K currents (I KAS) are upregulated in heart failure. We
hypothesize that apamin can flatten action potential duration restitution (APDR) curve and …