Systematic studies of the cancer genome have exploded in recent years. These studies
have revealed scores of new cancer genes, including many in processes not previously …

Cancer arises as a consequence of cumulative disruptions to cellular growth control with
Darwinian selection for those heritable changes that provide the greatest clonal advantage …

Summary N 6-methyladenosine (m 6 A) is a commonly present modification of mammalian
mRNAs and plays key roles in various cellular processes. m 6 A modifiers catalyze this …

In the past few years, it has become clear that mutations in epigenetic regulatory genes are
common in human cancers. Therapeutic strategies are now being developed to target …

We report germline missense mutations in ETV6 segregating with the dominant transmission
of thrombocytopenia and hematologic malignancy in three unrelated kindreds, defining a …

Acute myeloid leukemia (AML) comprises a heterogeneous group of leukemias frequently
defined by recurrent cytogenetic abnormalities, including rearrangements involving the core …

The discovery that ten-eleven translocation (TET) proteins are α-ketoglutarate-dependent
dioxygenases involved in the conversion of 5-methylcytosines (5-mC) to 5 …

Acute myeloid leukemia (AML) with an FLT3 internal tandem duplication (FLT3-ITD)
mutation is an aggressive hematologic malignancy with a grave prognosis. To identify the …

Hematologic malignancies are one of the most common cancers, and the incidence has
been rising in recent decades. The clinical and molecular features of hematologic …

DNA methylation has pivotal regulatory roles in mammalian development, retrotransposon
silencing, genomic imprinting, and X‐chromosome inactivation. Cancer cells display highly …