Anthracyclines, such as doxorubicin, are effective chemotherapeutic agents for the treatment
of cancer, but their clinical use is associated with severe and potentially life-threatening …

Chemotherapy and targeted therapies have significantly improved the prognosis of
oncology patients. However, these antineoplastic treatments may also induce adverse …

Anthracyclines have contributed significantly to remarkable improvements in overall survival
and are regarded as the most effective cytostatic drug for cancer treatment in various …

Anthracyclines, such as doxorubicin, represent one group of chemotherapy drugs with the
most cardiotoxicity. Despite that anthracyclines are capable of treating assorted solid tumors …

Chemotherapy, radiotherapy, targeted therapy, and immunotherapy have brought hope to
cancer patients. With the prolongation of survival of cancer patients and increased clinical …

Acquired drug resistance represents a major clinical problem and one of the biggest
limitations of chemotherapeutic regimens in colorectal cancer. Combination regimens using …

Doxorubicin (DOX) is an anticancer agent for treating solid and soft tissue malignancies.
However, the clinical use of DOX is restricted by cumulative, dose-dependent cardiotoxicity …

The myocardium is among the most energy-consuming tissues in the body, burning from 6 to
30 kg of ATP per day within the mitochondria, the so-called powerhouse of the …

Resistance to chemotherapy still remains a major challenge in the clinic, impairing the
quality of life and survival rate of patients. The identification of unconventional …

Background Despite recent advances in research, there are still critical lacunae in our basic
understanding of the cause, pathogenesis, and natural history of many cancers, especially …