Iron is an essential element for metabolic processes intrinsic to life, and yet the properties
that make iron a necessity also make it potentially deleterious. To avoid harm, iron …

Exosomes are 50–100 nm membranous vesicles actively released by cells which can be
indicative of a diseased cell status. They contain various kinds of molecule–proteins, mRNA …

Brain metastases are a common feature of malignant melanoma and are associated with
poor prognosis. Melanotransferrin (MTf), one of several antigens associated with the surface …

Melanotransferrin (MTf) or melanoma tumor antigen p97 is a transferrin (Tf) homolog that is
found predominantly bound to the cell membrane via a glycosyl phosphatidylinositol anchor …

BACKGROUND: Melanotransferrin was discovered in the 1980s as one of the first
melanoma tumour antigens. The molecule is a transferrin homologue that is found …

Platelet-derived growth factor (PDGF)–dependent recruitment of mural cells such as
pericytes and smooth muscle cells plays a central role in the maturation and stabilization of …

Melanotransferrin (MFI2) is a newly identified tumor-associated protein, which consists of
two forms of proteins, membrane-bound (mMFI2) and secretory (sMFI2). However, little is …

Angiogenesis occurs in pathological conditions, such as tumors, where a specific critical
point in tumor progression is the transition from the avascular to the vascular phase. Tumor …

Oral squamous cell carcinoma (OSCC) is the predominant histological type of the head and
neck squamous cell carcinoma (HNSCC). By comparing the differentially expressed genes …

Melanotransferrin is a glycoprotein expressed at the cell membrane and secreted in the
extracellular environment. Recombinant truncated form of membrane-bound …