Significance: Mitochondrial (mt) reticulum network in the cell possesses amazing
ultramorphology of parallel lamellar cristae, formed by the invaginated inner mitochondrial …

Historically, distinct mitochondrial syndromes were recognised clinically by their ocular
features. Due to their predilection for metabolically active tissue, mitochondrial diseases …

Hereditary optic neuropathies are caused by the degeneration of retinal ganglion cells
whose axons form the optic nerves, with a consistent genetic heterogeneity. As part of our …

This article describes the main visual electrodiagnostic tests relevant to neuro-
ophthalmology practice, including the visual evoked potential (VEP), and the full-field …

Pathological deterioration of mitochondrial function is increasingly linked with multiple
degenerative illnesses as a mediator of a wide range of neurologic and age-related chronic …

The complex relationship between mitochondrial dynamics and autophagy illustrates how
two cellular housekeeping processes are intimately linked, illuminating fundamental …

Mitochondria are essential organelles for cellular metabolism and physiology in eukaryotic
cells. Human mitochondria have their own genome (mtDNA), which is maternally inherited …

Leber's hereditary optic neuropathy (LHON) is a maternally transmitted eye disease due to
the degeneration of retinal ganglion cells (RGCs). Mitochondrial 11778G> A mutation is the …

Leber's hereditary optic neuropathy (LHON) is driven by mtDNA mutations affecting
Complex I presenting as progressive retinal ganglion cell dysfunction usually in the absence …

Ataxia is increasingly being recognized as a cardinal manifestation in primary mitochondrial
diseases (PMDs) in both paediatric and adult patients. It can be caused by disruption of …