Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Abstract The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in
malignant transformation, prevention of apoptosis, drug resistance and metastasis. The …

Abstract The EGFR/PI3K/PTEN/Akt/mTORC pathway plays prominent roles in malignant
transformation, prevention of apoptosis, drug resistance, cancer initiating cells (CICs) and …

Breast cancer is one of the most prevalent malignancies and the leading cause of cancer‑
associated mortality in women worldwide and in China. Everolimus (C53H83NO14) is an …

Chronological age represents the greatest risk factor for many life-threatening diseases,
including neurodegeneration, cancer, and cardiovascular disease; ageing also increases …

mTOR (mechanistic target of rapamycin) functions as the central regulator for cell
proliferation, growth and survival. Up-regulation of proteins regulating mTOR, as well as its …

Background: Resistance to endocrine treatment generally occurs over time, especially in the
metastatic stage. In this paper, we aimed to review the mechanisms of cyclin-dependent …

Recently, considerable attention in the field of cancer therapy has been focused on the
mammalian rapamycin target (mTOR), inhibition of which could result in autophagic cell …

Over the past 10 years there have been significant advances in our understanding of breast
cancer and the important roles that breast cancer initiating cells (CICs) play in the …

Abstract ABT-263 (navitoclax), a Bcl-2 family protein inhibitor, was clinically tested as an anti-
cancer agent. However, the clinical trials were limited given the occurrence of resistance to …