For decades, the hypothesis that brain deposition of the amyloid β protein initiates
Alzheimer's disease has dominated research and clinical trials. Targeting amyloid β is …

Postoperative cognitive dysfunction (POCD) has been reported with widely varying
frequency but appears to be strongly associated with aging. Outside of the surgical arena …

Evidence suggests exposure to particulate matter with aerodynamic diameter< 2.5 μm (PM2.
5) may increase the risk for Alzheimer's disease and related dementias. Whether PM2. 5 …

Alzheimer disease (AD) is the most common cause of dementia. Biological definitions of AD
are limited to the cerebral burden of amyloid β plaques, neurofibrillary pathology, and …

Despite growing evidence for the characteristic signs of Alzheimer's disease (AD) in the
neurosensory retina, our understanding of retina–brain relationships, especially at …

We previously showed that dual decline in memory and gait speed was associated with an
increased risk of dementia compared to memory or gait decline only or no decline. We now …

Objective To determine whether vascular and neurodegenerative factors influence cognition
before clinically relevant Alzheimer disease pathology, we analyzed MRI measures and …

White matter hyperintensities (WMHs) may be one of the earliest pathological changes in
aging. Race differences in WMH burden has been conflicting. This study examined if race …

Background: Understanding the neurobiological underpinnings between established
multimodal dementia risk factors and noninvasive blood-based biomarkers may lead to …

Background To explore whether the combination of white matter hyperintensities (WMHs)
and amyloid-beta (Aβ) deposition is associated with worse cognitive performance on …