Epigenomic and transcriptomic landscaping unraveled candidate repositioned therapeutics for non-functioning pituitary neuroendocrine tumors
Purpose Non-functioning pituitary neuroendocrine tumors are challengingly diagnosed
tumors in the clinic. Transsphenoidal surgery remains the first-line treatment. Despite the …
tumors in the clinic. Transsphenoidal surgery remains the first-line treatment. Despite the …
Transcriptome of GH-producing pituitary neuroendocrine tumours and models are significantly affected by somatostatin analogues
R Saksis, O Rogoza, H Niedra, K Megnis… - Cancer Cell …, 2023 - Springer
Pituitary neuroendocrine tumours (PitNETs) are neoplasms of the pituitary that overproduce
hormones or cause unspecific symptoms due to mass effect. Growth hormone …
hormones or cause unspecific symptoms due to mass effect. Growth hormone …
Pituitary surgery outcome in patients 75 years and older: a retrospective study
M Garvayo, C Villa, A Jouinot, M Messerer, V Reina… - Acta …, 2023 - Springer
Background As the population ages, the number of elderly patients with an indication for
pituitary surgery is rising. Information on the outcome of patients aged over 75 is limited. This …
pituitary surgery is rising. Information on the outcome of patients aged over 75 is limited. This …
JAG1, regulated by microRNA-424-3p, involved in tumorigenesis and epithelial–mesenchymal transition of high proliferative potential-pituitary adenomas
Y Chen, B Li, J Feng, Q Fang, J Cheng, W Xie… - Frontiers in …, 2020 - frontiersin.org
Pituitary adenomas (PAs) are a neoplastic proliferation of anterior pituitary. Signature of
Notch pathway relies upon the histopathological type of PAs. The details of Notch pathway …
Notch pathway relies upon the histopathological type of PAs. The details of Notch pathway …
Deep Learning model-based approach for preoperative prediction of Ki67 labeling index status in a noninvasive way using magnetic resonance images: A single …
X Shu, H Chang, Q Wang, W Chen, K Zhao, B Li… - Clinical Neurology and …, 2022 - Elsevier
Objectives Ki67 is an important biomarker of pituitary adenoma (PA) aggressiveness. In this
study, PA invasion of surrounding structures is investigated and deep learning (DL) models …
study, PA invasion of surrounding structures is investigated and deep learning (DL) models …
A nomogram for preoperatively predicting the Ki-67 index of a pituitary tumor: A retrospective cohort study
Background The Ki-67 index is an indicator of proliferation and aggressive behavior in
pituitary adenomas (PAs). This study aims to develop and validate a predictive nomogram …
pituitary adenomas (PAs). This study aims to develop and validate a predictive nomogram …
The expression of neural cell adhesion molecule and the microenvironment of pituitary neuroendocrine tumours
P Marques, S Barry, E Carlsen, D Collier… - Journal of …, 2021 - Wiley Online Library
The neural cell adhesion molecule (NCAM) has previously been studied in pituitary
neuroendocrine tumours (PitNETs), but its role in tumour biology and aggressiveness …
neuroendocrine tumours (PitNETs), but its role in tumour biology and aggressiveness …
Proposal of a clinically relevant working classification of pituitary neuroendocrine tumors based on pituitary transcription factors
S Silva-Ortega, A García-Martinez, MN de Jaime… - Human Pathology, 2021 - Elsevier
The immunohistochemistry (IHC) characterization of pituitary transcription factors (PTFs)
PIT1, TPIT, and SF1, which enable the identification of three different adenohypophyseal cell …
PIT1, TPIT, and SF1, which enable the identification of three different adenohypophyseal cell …
Comparative analysis of intraoperative and imaging features of invasive growth in pituitary adenomas
M Hladik, I Nasi-Kordhishti, L Dörner… - European Journal of …, 2024 - academic.oup.com
Abstract Background Most pituitary adenomas (PAs), also termed pituitary neuroendocrine
tumors, are benign in nature and can be treated effectively by surgical resection, medical …
tumors, are benign in nature and can be treated effectively by surgical resection, medical …
Histopathology of growth hormone-secreting pituitary tumors: state of the art and new perspectives
F Guaraldi, F Ambrosi, C Ricci, L Di Sciascio… - Best Practice & Research …, 2024 - Elsevier
Somatotroph (GH) adenomas/PitNETs typically arise from adenohypophysis and are
biochemically active, leading to acromegaly and gigantism. More rarely, they present with …
biochemically active, leading to acromegaly and gigantism. More rarely, they present with …