The pathogenesis of gastroesophageal reflux disease (GERD) is complex and involves
changes in reflux exposure, epithelial resistance, and visceral sensitivity. The gastric …

Up to 40% of patients with symptoms suspicious of gastroesophageal reflux disease (GERD)
do not respond completely to proton pump inhibitor (PPI) therapy. The term “refractory …

The public health importance of Barrett's oesophagus lies in its association with
oesophageal adenocarcinoma. The incidence of oesophageal adenocarcinoma has risen at …

Background Oesophageal intraluminal impedance is currently used for assessment of reflux
in gastro-oesophageal reflux disease (GORD). Oesophageal mucosa integrity may have a …

Patients with gastro-oesophageal reflux disease (GORD) who are not responding to proton
pump inhibitors (PPIs) given once daily are very common. Various underlying mechanisms …

Gastro-oesophageal reflux disease refers to reflux of gastric contents into the oesophagus
leading to oesophagitis, reflux symptoms sufficient to impair quality of life, or long-term …

Nonerosive reflux disease (NERD) represents the more common phenotypic presentation of
GERD and comprises patients who have typical symptoms without any mucosal breaks at …

Gastro-oesophageal reflux disease is one of the most common disorders of the
gastrointestinal tract. Over past decades, considerable shifts in thinking about the disease …

Recent data suggest that the interaction between gastroesophageal reflux disease (GERD)
and eosinophilic esophagitis can be complex, and that the notion of establishing a clear …

Background Despite gastro‐esophageal reflux disease affecting up to 20% of Western
populations, relatively little is known about the molecular mechanisms underlying its most …