Slit-Robo GTPase-Activating Protein 2 as a metastasis suppressor in osteosarcoma

TA Marko, GA Shamsan, EN Edwards, PE Hazelton… - Scientific reports, 2016 - nature.com
Osteosarcoma is the most common primary bone tumor, with metastatic disease responsible
for most treatment failure and patient death. A forward genetic screen utilizing Sleeping …

Comparative aspects of osteosarcoma pathogenesis in humans and dogs

TM Fan, C Khanna - Veterinary sciences, 2015 - mdpi.com
Osteosarcoma (OS) is a primary and aggressive bone sarcoma affecting the skeleton of two
principal species, human beings and canines. The biologic behavior of OS is conserved …

Operative treatment and outcomes of pediatric patients with an extremity bone tumor: a secondary analysis of the PARITY Trial data

A Bozzo, CM Yeung, M Van De Sande, M Ghert… - JBJS, 2023 - journals.lww.com
Background: Osteosarcoma and Ewing sarcoma are the 2 most common primary bone
sarcomas, occurring predominantly in pediatric patients, with the incidence of osteosarcoma …

Avenues of research in dietary interventions to target tumor metabolism in osteosarcoma

TC Leite, RJ Watters, KR Weiss, G Intini - Journal of Translational …, 2021 - Springer
Osteosarcoma (OS) is the most frequent primary bone cancer, affecting mostly children and
adolescents. Although much progress has been made throughout the years towards treating …

Nearly Half of TP53 Germline Variants Predicted To Be Pathogenic in Patients With Osteosarcoma Are De Novo: A Report From the Children's Oncology Group

BJ Diessner, N Pankratz, AJ Hooten… - JCO Precision …, 2020 - ascopubs.org
PURPOSE To ascertain the prevalence of recurrent de novo variants among 240 pediatric
patients with osteosarcoma (OS; age< 20 years) unselected for family history of cancer …

Genetics in orthopaedic practice

R Aicale, D Tarantino, G Maccauro, GM Peretti… - JOURNAL OF …, 2019 - air.unimi.it
DNA holds genetic information in the nucleus of eukaryotic cells; and has three different
functions: replication, storage of hereditary information, and regulation of cell division. Most …

Cold atmospheric plasma inhibits the growth of osteosarcoma cells by inducing apoptosis, independent of the device used

L Haralambiev, L Wien, N Gelbrich… - Oncology …, 2020 - spandidos-publications.com
Osteosarcoma (OS) is the most common tumor of the musculoskeletal system. Recently, cold
atmospheric plasma (CAP) has been regarded as a promising anti‑oncogenic therapy …

Orthopaedic applications of cold physical plasma

L Nonnenmacher, M Fischer… - EFORT Open …, 2023 - eor.bioscientifica.com
Cold physical plasma (CPP) technology is of high promise for various medical applications.
The interplay of specific components of physical plasma with living cells, tissues and organs …

Assessing the incidence of osteosarcoma among teriparatide users based on Medicare Part D and US State Cancer Registry Data

A Gilsenan, K Midkiff, D Harris… - … and Drug Safety, 2020 - Wiley Online Library
Purpose During preclinical testing, teriparatide caused a dose‐dependent increase in the
incidence of osteosarcoma in rats. This study compared the incidence rate of osteosarcoma …

Current state of pediatric sarcoma biology and opportunities for future discovery: A report from the sarcoma translational research workshop

P Hingorani, K Janeway, BD Crompton, C Kadoch… - Cancer genetics, 2016 - Elsevier
Sarcomas are a rare subgroup of pediatric cancers comprised of a variety of bone and soft-
tissue tumors. While significant advances have been made in improving outcomes of …