Angiogenic signaling pathways and anti-angiogenic therapy for cancer

ZL Liu, HH Chen, LL Zheng, LP Sun… - Signal transduction and …, 2023 - nature.com
Angiogenesis, the formation of new blood vessels, is a complex and dynamic process
regulated by various pro-and anti-angiogenic molecules, which plays a crucial role in tumor …

Treatment options in recurrent ovarian cancer: latest evidence and clinical potential

D Luvero, A Milani… - Therapeutic advances in …, 2014 - journals.sagepub.com
Ovarian cancer (OC) is the fifth most common cause of cancer death in women. Although
significant progress has been made in the treatment of OC, the majority of patients …

Nanoceria: a rare-earth nanoparticle as a novel anti-angiogenic therapeutic agent in ovarian cancer

S Giri, A Karakoti, RP Graham, JL Maguire, CM Reilly… - PloS one, 2013 - journals.plos.org
Ovarian cancer (OvCa) is the fifth most common cause of death from all cancers among
women in United Sates and the leading cause of death from gynecological malignancies …

Targeted therapies for ovarian cancer

T Grunewald, JA Ledermann - Best practice & research Clinical obstetrics & …, 2017 - Elsevier
Epithelial ovarian cancer has the highest mortality rate of all gynaecological malignancies.
Most women present with advanced disease and develop a recurrence after radical surgery …

Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance

CS Leung, TL Yeung, KP Yip, KK Wong… - The Journal of …, 2018 - Am Soc Clin Investig
The molecular mechanism by which cancer-associated fibroblasts (CAFs) confer
chemoresistance in ovarian cancer is poorly understood. The purpose of the present study …

Angiogenesis-related pathways in the pathogenesis of ovarian cancer

NG Gavalas, M Liontos, SP Trachana… - International journal of …, 2013 - mdpi.com
Ovarian Cancer represents the most fatal type of gynecological malignancies. A number of
processes are involved in the pathogenesis of ovarian cancer, especially within the tumor …

Malignant ascites in ovarian cancer and the role of targeted therapeutics

E Smolle, V Taucher, J Haybaeck - Anticancer research, 2014 - ar.iiarjournals.org
Ovarian cancer (OC) is the eighth most lethal gynecological malignancy and the main cause
of gynecological cancer death in industrialized countries. Malignant ascites is often found in …

Neo-vascularization-based therapeutic perspectives in advanced ovarian cancer

V Bhardwaj, X Zhang, V Pandey, M Garg - Biochimica et Biophysica Acta …, 2023 - Elsevier
The process of angiogenesis is well described for its potential role in the development of
normal ovaries, and physiological functions as well as in the initiation, progression, and …

Lymphatic vasculature in ovarian cancer

S Pal, S Bhowmick, A Sharma… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Ovarian cancer (OVCA) is the second most common gynecological cancer and one of the
leading causes of cancer related mortality among women. Recent studies suggest that …

Incorporation of anti-angiogenesis therapy in the management of advanced ovarian carcinoma—mechanistics, review of phase III randomized clinical trials, and …

RN Eskander, KS Tewari - Gynecologic oncology, 2014 - Elsevier
Despite survival gains achieved nearly two decades ago with combination platinum-and
taxane-based intravenous chemotherapy, overall survival curves have remained relatively …