Overcoming cancer chemotherapy resistance by the induction of ferroptosis

Y Wang, X Wu, Z Ren, Y Li, W Zou, J Chen… - Drug Resistance …, 2023 - Elsevier
Abstract Development of resistance to chemotherapy in cancer continues to be a major
challenge in cancer management. Ferroptosis, a unique type of cell death, is mechanistically …

Engineered exosomes from different sources for cancer-targeted therapy

M Zhang, S Hu, L Liu, P Dang, Y Liu, Z Sun… - Signal transduction and …, 2023 - nature.com
Exosome is a subgroup of extracellular vesicles, which has been serving as an efficient
therapeutic tool for various diseases. Engineered exosomes are the sort of exosomes …

Role of NRF2 in ovarian cancer

G Tossetta, S Fantone, E Montanari, D Marzioni… - Antioxidants, 2022 - mdpi.com
Among gynaecologic malignancies, ovarian cancer is one of the most dangerous, with a
high fatality rate and relapse due to the occurrence of chemoresistance. Many researchers …

Targeting the NRF2/KEAP1 pathway in cervical and endometrial cancers

G Tossetta, D Marzioni - European Journal of Pharmacology, 2023 - Elsevier
Cervical and endometrial cancers are among the most dangerous gynaecological
malignancies, with high fatality and recurrence rates due to frequent diagnosis at an …

Cisplatin for cancer therapy and overcoming chemoresistance

R Ranasinghe, ML Mathai, A Zulli - Heliyon, 2022 - cell.com
Cisplatin spearheads the anticancer chemotherapeutics in present-day use although acute
toxicity is its primary impediment factor. Among a plethora of experimental medications, a …

Cervical cancer heterogeneity: a constant battle against viruses and drugs

Q Sun, L Wang, C Zhang, Z Hong, Z Han - Biomarker Research, 2022 - Springer
Cervical cancer is the first identified human papillomavirus (HPV) associated cancer and the
most promising malignancy to be eliminated. However, the ever-changing virus subtypes …

linc00958/miR-185-5p/RSF-1 modulates cisplatin resistance and angiogenesis through AKT1/GSK3β/VEGFA pathway in cervical cancer

J Tian, L Cheng, E Kong, W Gu, Y Jiang, Q Hao… - Reproductive Biology …, 2022 - Springer
Background Chemoresistance is one of the major obstacles that lead to poor prognosis in
cervical cancer. linc00958 was reported to be an oncogene in cervical cancer. However, its …

Evaluation of long non-coding RNA (LncRNA) in the pathogenesis of chemotherapy resistance in cervical cancer: diagnostic and prognostic approach

N Modabber, SS Mahboub, S Khoshravesh… - Molecular …, 2023 - Springer
Cervical cancer (CC), caused by human papillomavirus (HPV), is a leading cause of female
malignancies worldwide. Therefore, understanding the underlying mechanisms of CC …

Circular RNA ARHGAP5 inhibits cisplatin resistance in cervical squamous cell carcinoma by interacting with AUF1

S Deng, L Qian, L Liu, H Liu, Z Xu, Y Liu… - Cancer …, 2023 - Wiley Online Library
Cervical squamous cell carcinoma (CSCC) is one of the leading causes of cancer death in
women worldwide. Patients with advanced cervical carcinoma always have a poor …

Downregulation of miR-21 as a promising strategy to overcome drug resistance in cancer

T Akhtarkhavari, AR Bahrami, MM Matin - European Journal of …, 2022 - Elsevier
Despite tremendous achievements in the field of targeted cancer therapy, chemotherapy is
still the main treatment option, which is challenged by acquired drug resistance. Various …