The skin is the front line of defense against insult and injury and contains many epidermal
and immune elements that comprise the skin-associated lymphoid tissue (SALT). The …

NOD-like receptor protein 3 (NLRP3), an important intracellular pattern recognition receptor,
is a component of the NLRP3 inflammasome along with apoptosis-associated speck-like …

Psoriasis is a prevalent, chronic inflammatory disease of the skin, mediated by crosstalk
between epidermal keratinocytes, dermal vascular cells, and immunocytes such as antigen …

Molecular and cellular understanding of psoriasis pathogenesis has evolved considerably
over the last 30 years beginning in the early 1980s when psoriasis was thought to be a skin …

Th17 and IL‐17 play important roles in the clearance of extracellular bacterial and fungal
infections. However, strong evidence also implicates the Th17 lineage in several …

This review discusses how oxidative stress (OS), an imbalance between oxidants and
antioxidants in favor of the oxidants, increased production of reactive oxygen species …

c-Jun is a major component of the dimeric transcription factor activator protein-1 (AP-1), a
paradigm for transcriptional response to extracellular signaling, whose components are …

Genetic mutations of CARD14 (encoding CARMA2) are observed in psoriasis patients. Here
we showed that Card14 E138A/+ and Card14 ΔQ136/+ mice developed spontaneous …

Abstract c-Jun, the most extensively studied protein of the activator protein-1 (AP-1)
complex, is involved in numerous cell activities, such as proliferation, apoptosis, survival …

Psoriasis is the most common skin disease in adults. Current experimental and clinical
evidences suggested the infiltrating immune cells could target local skin cells and thus …