The adaptive immune system arose 500 million years ago in ectothermic (cold-blooded)
vertebrates. Classically, the adaptive immune system has been defined by the presence of …

Over several decades, various forms of genomic analysis of the human major
histocompatibility complex (MHC) have been extremely successful in picking up many …

Major histocompatibility complex (MHC) genes have been put forward as a model for
studying how genetic diversity is maintained in wild populations. Pathogen-mediated …

The major histocompatibility complex (MHC) is the most important region in the vertebrate
genome with respect to infection and autoimmunity, and is crucial in adaptive and innate …

The major histocompatibility complex (MHC) has become a paradigm for how selection can
act to maintain adaptively important genetic diversity in natural populations. Here, we review …

A synergistic combination of two next-generation sequencing platforms with a detailed
comparative BAC physical contig map provided a cost-effective assembly of the genome …

There has been marked progress in our understanding of the role of natural killer (NK) cells
in immune responses, mainly due to the identification of NK-cell receptors and their ligands …

In the 1960s, when population geneticists first began to collect data on the amount of genetic
variation in natural populations, balancing selection was invoked as a possible explanation …

Abstract Analysis of the genomes of two distantly related bird species, chicken and zebra
finch (divergence of about 100 million years), indicate that there are ten avian toll-like …

Here we report the first complete sequence and gene map of a human major
histocompatibility complex (MHC), a region on chromosome 6 which is essential to the …