Dry powder inhalation: past, present and future

AH de Boer, P Hagedoorn, M Hoppentocht… - Expert opinion on …, 2017 - Taylor & Francis
Introduction: Early dry powder inhalers (DPIs) were designed for low drug doses in asthma
and COPD therapy. Nearly all concepts contained carrier-based formulations and lacked …

[HTML][HTML] Cell-penetrating peptides: Emerging tools for mRNA delivery

H Yokoo, M Oba, S Uchida - Pharmaceutics, 2021 - mdpi.com
Messenger RNAs (mRNAs) were previously shown to have great potential for preventive
vaccination against infectious diseases and therapeutic applications in the treatment of …

[HTML][HTML] Effective mRNA pulmonary delivery by dry powder formulation of PEGylated synthetic KL4 peptide

Y Qiu, RCH Man, Q Liao, KLK Kung, MYT Chow… - Journal of Controlled …, 2019 - Elsevier
Pulmonary delivery of messenger RNA (mRNA) has considerable potential as therapy or
vaccine for a range of lung diseases. Inhaled dry powder formulation of mRNA is particularly …

Particle engineering for pulmonary drug delivery

AHL Chow, HHY Tong, P Chattopadhyay… - Pharmaceutical …, 2007 - Springer
With the rapidly growing popularity and sophistication of inhalation therapy, there is an
increasing demand for tailor-made inhalable drug particles capable of affording the most …

Dry powder inhalers (DPIs)—a review of device reliability and innovation

N Islam, E Gladki - International journal of pharmaceutics, 2008 - Elsevier
A wide range of dry powder inhaler (DPI) devices are currently available on the market to
deliver drugs into lungs with a view to maximise drug delivery with low variability. DPIs also …

Engineering the right formulation for enhanced drug delivery

WR Ke, RYK Chang, HK Chan - Advanced Drug Delivery Reviews, 2022 - Elsevier
Dry powder inhalers (DPIs) can be used with a wide range of drugs such as small molecules
and biologics and offer several advantages for inhaled therapy. Early DPI products were …

Lactose characteristics and the generation of the aerosol

G Pilcer, N Wauthoz, K Amighi - Advanced drug delivery reviews, 2012 - Elsevier
The delivery efficiency of dry-powder products for inhalation is dependent upon the drug
formulation, the inhaler device, and the inhalation technique. Dry powder formulations are …

Targeted drug-aerosol delivery in the human respiratory system

C Kleinstreuer, Z Zhang… - Annu. Rev. Biomed. Eng., 2008 - annualreviews.org
Inhalation of drug aerosols is a modern pathway to combat lung diseases. It is also
becoming the preferred route for insulin delivery, pain management, cancer therapy, and …

A critical view on lactose-based drug formulation and device studies for dry powder inhalation: which are relevant and what interactions to expect?

AH de Boer, HK Chan, R Price - Advanced drug delivery reviews, 2012 - Elsevier
Many years of research have not led to a profound knowledge of the mechanisms involved
in the formulation and dispersion of carrier based mixtures for inhalation. Although it is well …

Physical characterization of component particles included in dry powder inhalers. I. Strategy review and static characteristics

AJ Hickey, HM Mansour, MJ Telko, Z Xu… - Journal of …, 2007 - Elsevier
The performance of dry powder aerosols for the delivery of drugs to the lungs has been
studied extensively in the last decade. The focus for different research groups has been on …