Glial cells in Alzheimer's disease: From neuropathological changes to therapeutic implications

MS Uddin, LW Lim - Ageing research reviews, 2022 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder that usually develops slowly and
progressively worsens over time. Although there has been increasing research interest in …

[HTML][HTML] Alzheimer's disease: treatment strategies and their limitations

E Passeri, K Elkhoury, M Morsink, K Broersen… - International journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is the most frequent case of neurodegenerative disease and is
becoming a major public health problem all over the world. Many therapeutic strategies …

[HTML][HTML] Cerebral small vessel disease alters neurovascular unit regulation of microcirculation integrity involved in vascular cognitive impairment

Q Yang, X Wei, B Deng, Z Chang, D Jin, Y Huang… - Neurobiology of …, 2022 - Elsevier
Cerebral small vessel disease (CSVD) is a generic term used for intracranial vascular
disorders caused by the structural changes of cerebral microvessels, including the small …

Intrinsically disordered proteins and proteins with intrinsically disordered regions in neurodegenerative diseases

O Coskuner-Weber, O Mirzanli, VN Uversky - Biophysical Reviews, 2022 - Springer
Many different intrinsically disordered proteins and proteins with intrinsically disordered
regions are associated with neurodegenerative diseases. These types of proteins including …

Role of melatonin in Alzheimer's disease: from preclinical studies to novel melatonin-based therapies

J Roy, KY Wong, L Aquili, MS Uddin, BC Heng… - Frontiers in …, 2022 - Elsevier
Melatonin and novel melatonin-based therapies such as melatonin-containing hybrid
molecules, melatonin analogues, and melatonin derivatives have been investigated as …

[HTML][HTML] Berberine improves cognitive impairment by simultaneously impacting cerebral blood flow and β-amyloid accumulation in an APP/tau/PS1 mouse model of …

C Ye, Y Liang, Y Chen, Y Xiong, Y She, X Zhong… - Cells, 2021 - mdpi.com
Alzheimer's disease (AD) is accompanied by β-amyloid (Aβ), neurofibrillary tangles, and
neuron cell death, and is one of the most commonly occurring diseases among the elderly …

[HTML][HTML] Sex differences between neuronal loss and the early onset of amyloid deposits and behavioral consequences in 5xFAD transgenic mouse as a model for …

CH Poon, STN Wong, J Roy, Y Wang, HWH Chan… - Cells, 2023 - mdpi.com
A promising direction in the research on Alzheimer's Disease (AD) is the identification of
biomarkers that better inform the disease progression of AD. However, the performance of …

Exploring the multifunctional role of melatonin in regulating autophagy and sleep to mitigate Alzheimer's disease neuropathology

MF Hossain, N Wang, R Chen, S Li, J Roy… - Ageing Research …, 2021 - Elsevier
Melatonin (MLT) is a neurohormone that is regulated by the circadian clock and plays
multifunctional roles in numerous neurodegenerative disorders, such as Alzheimer's …

[HTML][HTML] The monkey head mushroom and memory enhancement in Alzheimer's disease

Yanshree, WS Yu, ML Fung, CW Lee, LW Lim… - Cells, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder, and no effective treatments are
available to treat this disorder. Therefore, researchers have been investigating Hericium …

[HTML][HTML] The role of butyrylcholinesterase and iron in the regulation of cholinergic network and cognitive dysfunction in Alzheimer's disease pathogenesis

J Jasiecki, M Targońska, B Wasąg - International Journal of Molecular …, 2021 - mdpi.com
Alzheimer's disease (AD), the most common form of dementia in elderly individuals, is
marked by progressive neuron loss. Despite more than 100 years of research on AD, there …