Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …

Monoclonal antibodies (mAbs) hold promise in treating Parkinson's disease (PD), although
poor delivery to the brain hinders their therapeutic application. In the current study, it is …

Cells respond to environmental cues by mobilizing signal transduction cascades that
engage protein kinases and phosphoprotein phosphatases. Correct organization of these …

The voltage-gated potassium (Kv) channels, encoded by 40 genes, repolarize all electrically
excitable cells, including plant, cardiac, and neuronal cells. Although these genes were fully …

Understanding voltage-gated sodium (Nav) channels is significant since they generate
action potential. Nav channels consist of a pore domain (PD) and a voltage sensor domain …

Dopamine regulates reward, cognition, and locomotor functions. By mediating rapid
reuptake of extracellular dopamine, the dopamine transporter is critical for spatiotemporal …

Acral burning pain triggered by fever, thermal hyposensitivity and skin denervation are
hallmarks of small fibre neuropathy in Fabry disease, a life-threatening X-linked lysosomal …

KCNQ2 and KCNQ3 channels are associated with multiple neurodevelopmental disorders
and are also therapeutic targets for neurological and neuropsychiatric diseases. For more …

Unique features of sensory neuron subtypes are manifest by their distinct physiological and
pathophysiological functions. Using patch-clamp electrophysiology, Ca 2+ imaging, CGRP …

Spatiotemporal regulation of intracellular signaling molecules, such as the 3′, 5′-cyclic
adenosine monophosphate (cAMP)-dependent protein kinase (PKA), ensures proper …