The classic isoforms of myelin basic protein (MBP, 14–21.5 kDa) are essential to formation
of the multilamellar myelin sheath of the mammalian central nervous system (CNS). The …

Simple Summary Proline isomerization influences protein folding and function tremendously
and serves as a unique type of post-translational modification that regulates multiple …

Compact myelin comprises most of the dry weight of myelin, and its insulative nature is the
basis for saltatory conduction of nerve impulses. The major dense line (MDL) is a 3-nm …

In the central nervous system, oligodendrocytes synthesize a specialized membrane, the
myelin membrane, which enwraps the axons in a multilamellar fashion to provide fast action …

The overall charge content and the patterning of charged residues have a profound impact
on the conformational ensembles adopted by intrinsically disordered proteins. These …

ABSTRACT A majority of thousands of intracellular mammalian proteins are recognized by
proteasome only being conjugated with ubiquitin (Ub), representing a universal degradation …

Interaction of myelin basic protein (MBP) and the cytoplasmic leaflets of the oligodendrocyte
membrane is essential for the formation and compaction of the myelin sheath of the central …

Multiple sclerosis (MS) is correlated with increased deimination of myelin basic protein
(MBP) in the central nervous system. Here, the interaction of MBP C1 (charge:+ 19) and …

There is a well-documented relationship between cerebral vasculature and multiple
sclerosis (MS) lesions: abnormal accumulations of iron have been found in the walls of the …

Intrinsically-disordered proteins (IDPs) present a complex interplay of conformational
variability and multifunctionality, modulated by environment and post-translational …