Essential polyunsaturated fatty acids (PUFAs) have profound effects on brain development
and function. Abnormalities of PUFA status have been implicated in neuropsychiatric …

N-3 Polyunsaturated fatty acids have been shown to have potential beneficial effects for
chronic diseases including cancer, insulin resistance and cardiovascular disease …

Abstract (n-3) PUFA are a family of biologically active fatty acids. The simplest member of
this family, a-linolenic acid, can be converted to the more biologically active very long-chain …

Chronic inflammation is a key feature of insulin resistance and obesity. Toll‐Like Receptor 4
(TLR4), involved in modulating innate immunity, is an important mediator of insulin …

Ras proteins are proto-oncogenes that are frequently mutated in human cancers. Three
closely related isoforms, HRAS, KRAS and NRAS, are expressed in all cells and have …

Lipid rafts are membrane microdomains intimately associated with cell signaling. These
biochemical microstructures are characterized by their high contents of sphingolipids …

The inflammatory response is designed to help fight and clear infection, remove harmful
chemicals, and repair damaged tissue and organ systems. Although this process, in general …

The metabolic syndrome and atherosclerotic cardiovascular disease have long been linked
to dietary SFA intake and inflammation. Recent mechanistic insights into how SFAs and …

Fish oil, enriched in bioactive n-3 polyunsaturated fatty acids (PUFA), has been shown to
play a role in prevention of colon cancer. The effects of n-3 PUFA are pleiotropic and …

Obesity is a recognized epidemic worldwide, and the accumulation of excess free saturated
fatty acids (SFAs) in cells induces cellular lipotoxic damage and increases the risk of a wide …