Hepatic inflammatory responses in liver fibrosis

L Hammerich, F Tacke - Nature Reviews Gastroenterology & …, 2023 - nature.com
Chronic liver diseases such as nonalcoholic fatty liver disease (NAFLD) or viral hepatitis are
characterized by persistent inflammation and subsequent liver fibrosis. Liver fibrosis critically …

Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease–novel insights into cellular communication circuits

M Peiseler, R Schwabe, J Hampe, P Kubes… - Journal of …, 2022 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease and is
emerging as the leading cause of cirrhosis, liver transplantation and hepatocellular …

[HTML][HTML] Neutrophils in chronic inflammatory diseases

A Herrero-Cervera, O Soehnlein… - Cellular & molecular …, 2022 - nature.com
Chronic inflammation is a component of many disease conditions that affect a large group of
individuals worldwide. Chronic inflammation is characterized by persistent, low-grade …

[HTML][HTML] Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)

X Xu, KL Poulsen, L Wu, S Liu, T Miyata… - Signal transduction and …, 2022 - nature.com
Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …

[HTML][HTML] Metabolic-associated fatty liver disease and lipoprotein metabolism

J Heeren, L Scheja - Molecular metabolism, 2021 - Elsevier
Background Non-alcoholic fatty liver disease, or as recently proposed 'metabolic-associated
fatty liver disease'(MAFLD), is characterized by pathological accumulation of triglycerides …

[HTML][HTML] Current strategies for exosome cargo loading and targeting delivery

H Zeng, S Guo, X Ren, Z Wu, S Liu, X Yao - Cells, 2023 - mdpi.com
Extracellular vesicles (EVs) such as ectosomes and exosomes have gained attention as
promising natural carriers for drug delivery. Exosomes, which range from 30 to 100 nm in …

[HTML][HTML] MicroRNAs in non-alcoholic fatty liver disease: Progress and perspectives

MY Hochreuter, M Dall, JT Treebak, R Barrès - Molecular metabolism, 2022 - Elsevier
Background Non-alcoholic fatty liver disease (NAFLD) is a spectrum of disease ranging from
simple hepatic steatosis (NAFL) to non-alcoholic steatohepatitis (NASH) which may …

[HTML][HTML] Distinct histopathological phenotypes of severe alcoholic hepatitis suggest different mechanisms driving liver injury and failure

J Ma, A Guillot, Z Yang, B Mackowiak… - The Journal of …, 2022 - Am Soc Clin Investig
Intrahepatic neutrophil infiltration has been implicated in severe alcoholic hepatitis (SAH)
pathogenesis; however, the mechanism underlying neutrophil-induced injury in SAH …

Immune–metabolic interactions in homeostasis and the progression to NASH

JA Hoogerland, B Staels, D Dombrowicz - Trends in Endocrinology & …, 2022 - cell.com
The incidence of non-alcoholic fatty liver disease (NAFLD) has increased significantly over
the past two decades. NAFLD ranges from simple steatosis (NAFL) to nonalcoholic …

MicroRNA-223 attenuates hepatocarcinogenesis by blocking hypoxia-driven angiogenesis and immunosuppression

Y Fu, B Mackowiak, D Feng, H Lu, Y Guan, T Lehner… - Gut, 2023 - gut.bmj.com
Objective The current treatment for hepatocellular carcinoma (HCC) to block angiogenesis
and immunosuppression provides some benefits only for a subset of patients with HCC, thus …