Androgens are effective bronchodilators with anti-inflammatory properties: A potential alternative for asthma therapy
LM Montaño, E Flores-Soto, B Sommer… - Steroids, 2020 - Elsevier
Abstract Changes in plasma androgen levels in asthmatic men may be linked to asthma
severity, seemingly acting through nongenomic and genomic effects. Nongenomic effects …
severity, seemingly acting through nongenomic and genomic effects. Nongenomic effects …
[HTML][HTML] ZIP9 but not the androgen receptor mediates testosterone-induced migratory activity of metastatic prostate cancer cells
A Bulldan, JW Bartsch, L Konrad… - Biochimica et Biophysica …, 2018 - Elsevier
LNCaP cells are derived from a metastatic lesion of human prostate adenocarcinoma. They
express the classical androgen receptor (AR) and ZIP9, a Zn 2+ transporter that also binds …
express the classical androgen receptor (AR) and ZIP9, a Zn 2+ transporter that also binds …
Testosterone facilitates nonreproductive, context-appropriate pro-and anti-social behavior in female and male Mongolian gerbils
AM Kelly, RR Thompson - Hormones and Behavior, 2023 - Elsevier
A growing body of literature suggests that testosterone (T) rapidly modulates behavior in a
context-specific manner. However, the timescales in which T can rapidly mediate distinct …
context-specific manner. However, the timescales in which T can rapidly mediate distinct …
Nuclear and membrane receptors for sex steroids are involved in the regulation of Delta/Serrate/LAG-2 proteins in rodent sertoli cells
S Lustofin, A Kamińska, M Brzoskwinia, J Cyran… - International journal of …, 2022 - mdpi.com
Delta/Serrate/LAG-2 (DSL) proteins, which serve as ligands for Notch receptors, mediate
direct cell–cell interactions involved in the determination of cell fate and functioning. The …
direct cell–cell interactions involved in the determination of cell fate and functioning. The …
Non-classical testosterone signaling in spermatogenic GC-2 cells is mediated through ZIP9 interacting with Gnα11
M Shihan, KH Chan, L Konrad, G Scheiner-Bobis - Cellular signalling, 2015 - Elsevier
Although classical and non-classical signaling of testosterone has been documented in
several investigations, the nature of the receptor involved in the non-classical pathway …
several investigations, the nature of the receptor involved in the non-classical pathway …
ZIP9 is a druggable determinant of sex differences in melanoma
C Aguirre-Portolés, R Payne, A Trautz, JK Foskett… - Cancer research, 2021 - AACR
Melanoma and most other cancers occur more frequently and have worse prognosis in
males compared with females. Although sex steroids are thought to be involved, classical …
males compared with females. Although sex steroids are thought to be involved, classical …
Androgens promote vascular endothelial cell proliferation through activation of a ZIP9-dependent inhibitory G protein/PI3K-Akt/Erk/cyclin D1 pathway
A Converse, P Thomas - Molecular and Cellular Endocrinology, 2021 - Elsevier
While androgens have been reported to mediate cardiovascular endothelial cell
proliferation, the potential involvement of membrane androgen receptors (mAR) has not …
proliferation, the potential involvement of membrane androgen receptors (mAR) has not …
Effects of hypoxia exposure on apoptosis and expression of membrane steroid receptors, ZIP9, mPRα, and GPER in Atlantic croaker ovaries
K Ondricek, P Thomas - Comparative Biochemistry and Physiology Part A …, 2018 - Elsevier
Hypoxia exposure causes endocrine disruption in croaker resulting in impairment of ovarian
growth and oocyte development, but the effects of hypoxia on non-classical steroid actions …
growth and oocyte development, but the effects of hypoxia on non-classical steroid actions …
How do elevated levels of testosterone affect the function of the human fallopian tube and fertility?—New insights
K Dulohery, M Trottmann, S Bour… - Molecular …, 2020 - Wiley Online Library
Excess testosterone levels affect up to 20% of the female population worldwide and are a
key component in the pathogenesis of polycystic ovary syndrome. However, little is known …
key component in the pathogenesis of polycystic ovary syndrome. However, little is known …
Membrane androgen receptor ZIP9 induces croaker ovarian cell apoptosis via stimulatory G protein alpha subunit and MAP kinase signaling
Recent studies show that androgen-induced apoptosis in Atlantic croaker primary granulosa
and theca (G/T) cells and in human breast and prostate cancer cell lines is mediated by the …
and theca (G/T) cells and in human breast and prostate cancer cell lines is mediated by the …