D-dimer is a soluble fibrin degradation product deriving from the plasmin-mediated
degradation of cross-linked fibrin. D-dimer can hence be considered a biomarker of …

ContextDyspnea is a common complaint in the emergency department where physicians
must accurately make a rapid diagnosis. ObjectiveTo assess the usefulness of history …

Description: Pulmonary embolism (PE) can be a severe disease and is difficult to diagnose,
given its nonspecific signs and symptoms. Because of this, testing patients with suspected …

Background: International guidelines include several strategies for diagnosing pulmonary
embolism with confidence, but little is known about how these guidelines are implemented …

Objectives To assess the likelihood ratios of diagnostic strategies for pulmonary embolism
and to determine their clinical application according to pretest probability. Data sources …

OBJECTIVES: To characterize physiological variation in hospitalized older adults with
severe coronary artery disease (CAD) and evaluate the prevalence of frailty in this sample …

The Wells rule is a widely applied clinical decision rule in the diagnostic work-up of patients
with suspected pulmonary embolism (PE). The objective of this study was to replicate …

Objective To validate the use of the Wells clinical decision rule combined with a point of care
D-dimer test to safely exclude pulmonary embolism in primary care. Design Prospective …

Study objective The assessment of clinical probability (as low, moderate, or high) with
clinical decision rules has become a cornerstone of diagnostic strategy for patients with …

Objective To derive and validate an objective clinical prediction rule for the presence of
uncomplicated ureteral stones in patients eligible for computed tomography (CT). We …