Hypoxia represents a frequent player in a number of malignancies, contributing to the
development of the neoplastic disease. This review will discuss the means by which hypoxia …

Hypoxia and inflammation are frequently co-incidental features of the tissue
microenvironment in a wide range of inflammatory diseases. While the impact of hypoxia on …

Solid tumors often grow in a micro-environment characterized by< 2% O 2 tension. This
condition, together with the aberrant activation of specific oncogenic patwhays, increases …

Background Hypoxia has long been considered as a hallmark of solid tumors and is closely
associated with tumor progression. Circular RNAs (circRNAs) have been identified as a …

In solid tumours, cancer cells exist within hypoxic microenvironments, and their metabolic
adaptation to this hypoxia is driven by HIF-1 transcription factor, which is overexpressed in a …

The hypoxia-inducible factors (HIF) are transcription factors that activate the adaptive
hypoxic response when oxygen levels are low. The HIF transcriptional program increases …

Hypoxia has been shown to increase the aggressiveness and severity of tumor progression.
Along with chronic and acute hypoxic regions, solid tumors contain regions of cycling …

During hypoxia, a cellular adaptive response activates hypoxia-inducible factors (HIFs; HIF-
1 and HIF-2) that respond to low tissue-oxygen levels and induce the expression of a …

Myocardial ischemia‑reperfusion injury (MIRI) is a severe injury to the ischemic myocardium
following the recovery of blood flow. Currently, there is no effective treatment for MIRI in …

Cardiovascular diseases are the leading cause of death worldwide. During the development
of cardiovascular diseases, hypoxia plays a crucial role. Hypoxia-inducible factors (HIFs) are …