[HTML][HTML] Hypoxia: overview on hypoxia-mediated mechanisms with a focus on the role of HIF genes
AA Tirpe, D Gulei, SM Ciortea, C Crivii… - International journal of …, 2019 - mdpi.com
Hypoxia represents a frequent player in a number of malignancies, contributing to the
development of the neoplastic disease. This review will discuss the means by which hypoxia …
development of the neoplastic disease. This review will discuss the means by which hypoxia …
[HTML][HTML] Regulation of the hypoxia-inducible factor (HIF) by pro-inflammatory cytokines
MI Malkov, CT Lee, CT Taylor - Cells, 2021 - mdpi.com
Hypoxia and inflammation are frequently co-incidental features of the tissue
microenvironment in a wide range of inflammatory diseases. While the impact of hypoxia on …
microenvironment in a wide range of inflammatory diseases. While the impact of hypoxia on …
[HTML][HTML] Hypoxia, endoplasmic reticulum stress and chemoresistance: dangerous liaisons
M Akman, DC Belisario, IC Salaroglio… - Journal of Experimental …, 2021 - Springer
Solid tumors often grow in a micro-environment characterized by< 2% O 2 tension. This
condition, together with the aberrant activation of specific oncogenic patwhays, increases …
condition, together with the aberrant activation of specific oncogenic patwhays, increases …
[HTML][HTML] Hypoxia-induced circWSB1 promotes breast cancer progression through destabilizing p53 by interacting with USP10
R Yang, H Chen, L Xing, B Wang, M Hu, X Ou, H Chen… - Molecular cancer, 2022 - Springer
Background Hypoxia has long been considered as a hallmark of solid tumors and is closely
associated with tumor progression. Circular RNAs (circRNAs) have been identified as a …
associated with tumor progression. Circular RNAs (circRNAs) have been identified as a …
[HTML][HTML] HIF-1-independent mechanisms regulating metabolic adaptation in hypoxic cancer cells
In solid tumours, cancer cells exist within hypoxic microenvironments, and their metabolic
adaptation to this hypoxia is driven by HIF-1 transcription factor, which is overexpressed in a …
adaptation to this hypoxia is driven by HIF-1 transcription factor, which is overexpressed in a …
[HTML][HTML] The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability
M Jaśkiewicz, A Moszyńska, J Króliczewski… - Cellular & molecular …, 2022 - Springer
The hypoxia-inducible factors (HIF) are transcription factors that activate the adaptive
hypoxic response when oxygen levels are low. The HIF transcriptional program increases …
hypoxic response when oxygen levels are low. The HIF transcriptional program increases …
[HTML][HTML] Acute vs. chronic vs. cyclic hypoxia: their differential dynamics, molecular mechanisms, and effects on tumor progression
K Saxena, MK Jolly - Biomolecules, 2019 - mdpi.com
Hypoxia has been shown to increase the aggressiveness and severity of tumor progression.
Along with chronic and acute hypoxic regions, solid tumors contain regions of cycling …
Along with chronic and acute hypoxic regions, solid tumors contain regions of cycling …
[HTML][HTML] Primary endothelial cell–specific regulation of hypoxia-inducible factor (HIF)-1 and HIF-2 and their target gene expression profiles during hypoxia
R Bartoszewski, A Moszyńska, M Serocki… - The FASEB …, 2019 - ncbi.nlm.nih.gov
During hypoxia, a cellular adaptive response activates hypoxia-inducible factors (HIFs; HIF-
1 and HIF-2) that respond to low tissue-oxygen levels and induce the expression of a …
1 and HIF-2) that respond to low tissue-oxygen levels and induce the expression of a …
[HTML][HTML] HIF‑1α in myocardial ischemia‑reperfusion injury
J Zheng, P Chen, J Zhong… - Molecular …, 2021 - spandidos-publications.com
Myocardial ischemia‑reperfusion injury (MIRI) is a severe injury to the ischemic myocardium
following the recovery of blood flow. Currently, there is no effective treatment for MIRI in …
following the recovery of blood flow. Currently, there is no effective treatment for MIRI in …
The role of hypoxia-inducible factors in cardiovascular diseases
B Yu, X Wang, Y Song, G Xie, S Jiao, L Shi… - Pharmacology & …, 2022 - Elsevier
Cardiovascular diseases are the leading cause of death worldwide. During the development
of cardiovascular diseases, hypoxia plays a crucial role. Hypoxia-inducible factors (HIFs) are …
of cardiovascular diseases, hypoxia plays a crucial role. Hypoxia-inducible factors (HIFs) are …