The comet assay in animal models: From bugs to whales–(Part 2 Vertebrates)
The comet assay has become one of the methods of choice for the evaluation and
measurement of DNA damage. It is sensitive, quick to perform and relatively affordable for …
measurement of DNA damage. It is sensitive, quick to perform and relatively affordable for …
[HTML][HTML] Purine metabolism regulates DNA repair and therapy resistance in glioblastoma
Intratumoral genomic heterogeneity in glioblastoma (GBM) is a barrier to overcoming
therapy resistance. Treatments that are effective independent of genotype are urgently …
therapy resistance. Treatments that are effective independent of genotype are urgently …
[HTML][HTML] NAMPT-derived NAD+ fuels PARP1 to promote skin inflammation through parthanatos cell death
FJ Martínez-Morcillo, J Cantón-Sandoval… - PLoS …, 2021 - journals.plos.org
Several studies have revealed a correlation between chronic inflammation and nicotinamide
adenine dinucleotide (NAD+) metabolism, but the precise mechanism involved is unknown …
adenine dinucleotide (NAD+) metabolism, but the precise mechanism involved is unknown …
Viral modulation of the DNA damage response and innate immunity: two sides of the same coin
A Lopez, RN Doyle, C Sandoval, K Nisson… - Journal of molecular …, 2022 - Elsevier
The DDR consists of multiple pathways that sense, signal, and respond to anomalous DNA.
To promote efficient replication, viruses have evolved to engage and even modulate the …
To promote efficient replication, viruses have evolved to engage and even modulate the …
[HTML][HTML] Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activity
Abstract Changes in nicotinamide adenine dinucleotide (NAD+) levels that compromise
mitochondrial function trigger release of DNA damaging reactive oxygen species. NAD+ …
mitochondrial function trigger release of DNA damaging reactive oxygen species. NAD+ …
Effects of low-level imidacloprid oral exposure on cholinesterase activity, oxidative stress responses, and primary DNA damage in the blood and brain of male Wistar …
Imidacloprid is a neonicotinoid insecticide that acts selectively as an agonist on insect
nicotinic acetylcholine receptors. It is used for crop protection worldwide, as well as for non …
nicotinic acetylcholine receptors. It is used for crop protection worldwide, as well as for non …
Toxicity of single-walled carbon nanotubes (SWCNTs): effect of lengths, functional groups and electronic structures revealed by a quantitative toxicogenomics assay
Single-walled carbon nanotubes (SWCNTs) are a group of widely used carbon-based
nanomaterials (CNMs) with various applications, which have caused increasing public …
nanomaterials (CNMs) with various applications, which have caused increasing public …
[HTML][HTML] Tenofovir-tethered gold nanoparticles as a novel multifunctional long-acting anti-HIV therapy to overcome deficient drug delivery-: an in vivo proof of concept
L Fotooh Abadi, P Kumar, K Paknikar… - Journal of …, 2023 - Springer
Abstract Background The adoption of Antiretroviral Therapy (ART) substantially extends the
life expectancy and quality of HIV-infected patients. Yet, eliminating the latent reservoirs of …
life expectancy and quality of HIV-infected patients. Yet, eliminating the latent reservoirs of …
[PDF][PDF] Scopoletin exerts anticancer effects on human cervical cancer cell lines by triggering apoptosis, cell cycle arrest, inhibition of cell invasion and PI3K/AKT …
Q Tian, L Wang, X Sun, F Zeng, Q Pan, M Xue - J BUON, 2019 - jbuon.com
Purpose: Cervical cancer causes considerable mortality in women world over and the
current treatment options create severe adverse effects. Hence, there is an urgent need to …
current treatment options create severe adverse effects. Hence, there is an urgent need to …
[HTML][HTML] Polyphenolic fraction from olive mill wastewater: Scale-up and in vitro studies for ophthalmic nutraceutical applications
MD Di Mauro, G Fava, M Spampinato, D Aleo, B Melilli… - Antioxidants, 2019 - mdpi.com
The valorization of food wastes is a challenging opportunity for a green, sustainable, and
competitive development of industry. Approximately 30 million m3 of olive mill wastewater …
competitive development of industry. Approximately 30 million m3 of olive mill wastewater …