Herein, we review mechanisms regulating cerebral blood flow (CBF), with specific focus on
humans. We revisit important concepts from the older literature and describe the interaction …

Cerebrovascular reactivity is the change in cerebral blood flow in response to a vasodilatory
or vasoconstrictive stimulus. Measuring variations of cerebrovascular reactivity between …

Background Guidelines recommend normocapnia for adults with coma who are resuscitated
after out-of-hospital cardiac arrest. However, mild hypercapnia increases cerebral blood flow …

Key points• The partial pressures of arterial carbon dioxide () and oxygen () has a marked
influence on brain blood flow.• It is unclear if the larger brain arteries are also sensitive to …

Opioid drugs are important tools to alleviate pain of different origins, but they have strong
addictive potential and their abuse at higher doses often results in serious health …

Purpose We assessed the effects of targeting low-normal or high-normal arterial carbon
dioxide tension (PaCO 2) and normoxia or moderate hyperoxia after out-of-hospital cardiac …

Rationale: Large decreases in PaCO2 that occur when initiating extracorporeal membrane
oxygenation (ECMO) in patients with respiratory failure may cause cerebral vasoconstriction …

Rationale Xylazine has emerged in recent years as an adulterant in an increasing number of
opioid-positive overdose deaths in the United States. Although its exact role in opioid …

In response to a surge of deaths from synthetic opioid overdoses, there have been
increased efforts to distribute naloxone products in community settings. Prior research has …

Vascular contributions to early cognitive decline are increasingly recognized, prompting
further investigation into the nature of related changes in perivascular spaces (PVS). Using …