Single-stranded RNA molecules fold into extraordinarily complicated secondary and tertiary
structures as a result of intramolecular base pairing. In vivo, these RNA structures are not …

A poly (A) tail is found at the 3 end of nearly every fully processed eukaryotic mRNA and has
been suggested to influence virtually all aspects of mRNA metabolism. Its proposed …

Formation of mRNA 3′ ends in eukaryotes requires the interaction of transacting factors
with cis-acting signal elements on the RNA precursor by two distinct mechanisms, one for …

Recent advances in the understanding of the molecular mechanism of mRNA 3′ end
processing have uncovered a previously unanticipated integrated network of transcriptional …

In mammals, polyadenylation of mRNA precursors (pre‐mRNAs) by poly (A) polymerase
(PAP) depends on cleavage and polyadenylation specificity factor (CPSF). CPSF is a …

Ends of almost all eukaryotic mRNAs are generated by endonucleolytic cleavage and
addition of a poly (A) tail. In mammalian cells, the reaction depends on the sequence …

Polyadenylation is an essential step for the maturation of almost all cellular mRNAs in
eukaryotes. In human cells, most poly (A) sites are flanked by the upstream AAUAAA …

The 3′‐ends of almost all eukaryotic mRNAs are formed in a two‐step process, an
endonucleolytic cleavage followed by polyadenylation (the addition of a poly‐adenosine or …

Eukaryotic pre-mRNAs are capped at their 5′ ends, polyadenylated at their 3′ ends, and
spliced before being exported from the nucleus to the cytoplasm. Although the three …

Abstract Four polypeptides of 25, 59, 68, and 72 kDa copurify with the activity of human
cleavage factor I m (CF I m) involved in pre-mRNA 3′ end processing. We report here the …