Over the past decade, non-coding RNA-based therapeutics have proven as a great potential
for the development of targeted therapies for cancer and other diseases. The discovery of …

RNA interference (RNAi) provides researchers with a versatile means to modulate target
gene expression. The major forms of RNAi molecules, genome-derived microRNAs …

Background miRNAs, a class of small endogenous RNAs, are one of the essential
biopharmaceuticals which are in commercial spans as next-generation medicine in recent …

Recent advancements in the production, modification, and cellular delivery of RNA
molecules facilitated the expansion of RNA-based therapeutics. The increasing …

Altered by defects in p53, epigenetic silencing, and genomic loss, the microRNA miR-34a
represents one of the most clinically relevant tumor-suppressive microRNAs. Without …

Diabetic wounds are one of the debilitating complications that affect up to 20% of diabetic
patients. Despite the advent of extensive therapies, the recovery rate is unsatisfactory, and …

Abstract Phosphoinositide-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR)
signaling pathway is one of the most important proliferative signaling pathways with critical …

Mesenchymal stem cells (MSCs) are known as promising sources for cancer therapy and
can be utilized as vehicles in cancer gene therapy. MSC-derived exosomes are central …

MicroRNA (miRNA) is regarded as a prominent genetic regulator, as it can fine‐tune an
entire biological pathway by targeting multiple target genes. This characteristic makes …

Multi-pathway approaches for the treatment of complex polygenic disorders are emerging as
alternatives to classical monotarget therapies and microRNAs are of particular interest in …