Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

COVID-19 convalescent plasma for the treatment of immunocompromised patients: a systematic review and meta-analysis

JW Senefeld, M Franchini, C Mengoli… - JAMA Network …, 2023 - jamanetwork.com
Importance Patients who are immunocompromised have increased risk for morbidity and
mortality associated with coronavirus disease 2019 (COVID-19) because they less …

Convalescent plasma for covid-19–induced ARDS in mechanically ventilated patients

B Misset, M Piagnerelli, E Hoste… - … England Journal of …, 2023 - Mass Medical Soc
Background Passive immunization with plasma collected from convalescent patients has
been regularly used to treat coronavirus disease 2019 (Covid-19). Minimal data are …

Antibody and B cell responses to SARS-CoV-2 infection and vaccination: the end of the beginning

K Röltgen, SD Boyd - Annual Review of Pathology: Mechanisms …, 2024 - annualreviews.org
As the COVID-19 pandemic has evolved during the past years, interactions between human
immune systems, rapidly mutating and selected SARS-CoV-2 viral variants, and effective …

The Omicron variant of concern: Diversification and convergent evolution in spike protein, and escape from anti-Spike monoclonal antibodies

D Focosi, S McConnell, A Casadevall - Drug Resistance Updates, 2022 - Elsevier
Abstract WHO-defined SARS-CoV-2 variants of concern (VOC) drive therapeutics and
vaccine development. The Omicron VOC is dominating the arena since November 2021, but …

Interaction of SARS-CoV-2 with host cells and antibodies: experiment and simulation

H Nguyen, HL Nguyen, PD Lan, NQ Thai… - Chemical Society …, 2023 - pubs.rsc.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …

Convalescent plasma therapy in COVID-19: Unravelling the data using the principles of antibody therapy

A Casadevall, MJ Joyner, LA Pirofski… - Expert review of …, 2023 - Taylor & Francis
Introduction When the COVID-19 pandemic struck no specific therapies were available and
many turned to COVID-19 convalescent plasma (CCP), a form of antibody therapy. The …

SARS-CoV-2 in immunocompromised individuals

S DeWolf, JC Laracy, MA Perales, M Kamboj… - Immunity, 2022 - cell.com
Immunocompromised individuals and particularly those with hematologic malignancies are
at increased risk for SARS-CoV-2-associated morbidity and mortality due to immunologic …

The potential role of passive antibody-based therapies as treatments for monkeypox

EM Bloch, DJ Sullivan, S Shoham, AAR Tobian… - Mbio, 2022 - Am Soc Microbiol
Monkeypox, a zoonosis caused by the orthopox monkeypox virus (MPXV) that is endemic to
Central and West Africa, was previously linked to sporadic outbreaks and rare, travel …

A randomized controlled study assessing convalescent immunoglobulins vs convalescent plasma for hospitalized patients with Coronavirus 2019

Y Maor, E Shinar, M Izak, G Rahav… - Clinical Infectious …, 2023 - academic.oup.com
Background It is unknown whether convalescent immunoglobulins (cIgGs) are better than
convalescent plasma (CP) for patients with coronavirus 2019 (COVID-19). Methods In this …