[HTML][HTML] Cancer immunotherapy resistance based on immune checkpoints inhibitors: Targets, biomarkers, and remedies
E Pérez-Ruiz, I Melero, J Kopecka… - Drug Resistance …, 2020 - Elsevier
Cancer is one of the main public health problems in the world. Systemic therapies such as
chemotherapy and more recently target therapies as well as immunotherapy have improved …
chemotherapy and more recently target therapies as well as immunotherapy have improved …
Acquired resistance to cancer immunotherapy: Role of tumor-mediated immunosuppression
In the tumor microenvironment (TME), tumor cells are constantly evolving to reduce
neoantigen generation and the mutational burden to escape the anti-tumor response. This …
neoantigen generation and the mutational burden to escape the anti-tumor response. This …
Tumor-associated macrophages: role in cancer development and therapeutic implications
A Salmaninejad, SF Valilou, A Soltani, S Ahmadi… - Cellular oncology, 2019 - Springer
Abstract Background Tumor-associated macrophages (TAMs) are known to play important
roles in the initiation and progression of human cancers, as well as in angiogenesis. TAMs …
roles in the initiation and progression of human cancers, as well as in angiogenesis. TAMs …
Crosstalk between DNA damage and inflammation in the multiple steps of carcinogenesis
S Kawanishi, S Ohnishi, N Ma, Y Hiraku… - International journal of …, 2017 - mdpi.com
Inflammation can be induced by chronic infection, inflammatory diseases and
physicochemical factors. Chronic inflammation is estimated to contribute to approximately …
physicochemical factors. Chronic inflammation is estimated to contribute to approximately …
[HTML][HTML] Antitumor effects of immunity-enhancing traditional Chinese medicine
Y Wang, Q Zhang, Y Chen, CL Liang, H Liu… - Biomedicine & …, 2020 - Elsevier
Abstract Traditional Chinese Medicine (TCM) has been traditionally used to treat patients
with cancers in China. It not only alleviates the symptoms of tumor patients and improves …
with cancers in China. It not only alleviates the symptoms of tumor patients and improves …
[HTML][HTML] 3D-3-culture: A tool to unveil macrophage plasticity in the tumour microenvironment
SP Rebelo, C Pinto, TR Martins, N Harrer, MF Estrada… - Biomaterials, 2018 - Elsevier
The tumour microenvironment (TME) shapes disease progression and influences
therapeutic response. Most aggressive solid tumours have high levels of myeloid cell …
therapeutic response. Most aggressive solid tumours have high levels of myeloid cell …
Progress on modulating tumor‐associated macrophages with biomaterials
M Sylvestre, CA Crane, SH Pun - Advanced Materials, 2020 - Wiley Online Library
Tumor‐associated macrophages (TAMs) are a complex and heterogeneous population of
cells within the tumor microenvironment. In many tumor types, TAMs contribute toward tumor …
cells within the tumor microenvironment. In many tumor types, TAMs contribute toward tumor …
[HTML][HTML] RNA nanotechnology-mediated cancer immunotherapy
RNA molecules (eg, siRNA, microRNA, and mRNA) have shown tremendous potential for
immunomodulation and cancer immunotherapy. They can activate both innate and adaptive …
immunomodulation and cancer immunotherapy. They can activate both innate and adaptive …
Targeting the Stat6 pathway in tumor‐associated macrophages reduces tumor growth and metastatic niche formation in breast cancer
Tumor‐associated macrophages (TAMs) are the key effector cells in the tumor
microenvironment and induce neoangiogenesis, matrix remodeling, and metastasis while …
microenvironment and induce neoangiogenesis, matrix remodeling, and metastasis while …