Semaglutide reduces alcohol intake and relapse-like drinking in male and female rats

C Aranäs, CE Edvardsson, OT Shevchouk, Q Zhang… - …, 2023 - thelancet.com
Background Glucagon-like peptide1 receptor (GLP-1R) agonists have been found to reduce
alcohol drinking in rodents and overweight patients with alcohol use disorder (AUD) …

New insights into the molecular basis of alcohol abstinence and relapse in alcohol-associated liver disease

LA Diaz, GS Winder, L Leggio, JS Bajaj, R Bataller… - Hepatology, 2023 - journals.lww.com
Alcohol use disorder (AUD) remains a significant public health concern, affecting around 5%
of adults worldwide. Novel pathways of damage have been described during the last years …

Emerging targets for therapy in ALD: Lessons from NASH

AK Singal, VH Shah, H Malhi - Hepatology, 2024 - journals.lww.com
Alcohol-associated liver disease due to harmful alcohol use and NAFLD associated with
metabolic syndrome are the 2 most common liver diseases worldwide. Control of respective …

Des-acyl ghrelin reduces alcohol intake and alcohol-induced reward in rodents

S Witley, CE Edvardsson, C Aranäs… - Translational …, 2024 - nature.com
The mechanisms contributing to alcohol use disorder (AUD) are complex and the orexigenic
peptide ghrelin, which enhances alcohol reward, is implied as a crucial modulator. The …

Antismoking agents do not contribute synergistically to semaglutide's ability to reduce alcohol intake in rats

C Aranäs, S Blid Sköldheden, E Jerlhag - Frontiers in Pharmacology, 2023 - frontiersin.org
Preclinical studies have identified glucagon-like peptide-1 receptor (GLP-1R) agonists, and
the antismoking agents varenicline and bupropion as tentative agents for treatment of …

[HTML][HTML] Role of ghrelin hormone in the development of alcohol-associated liver disease

S Mahalingam, R Bellamkonda, KK Kharbanda… - Biomedicine & …, 2024 - Elsevier
Fatty liver is the earliest response of the liver to excessive alcohol consumption. Previously
we identified that chronic alcohol administration increases levels of stomach-derived …

[HTML][HTML] The Contribution of the Brain–Gut Axis to the Human Reward System

K Karaivazoglou, I Aggeletopoulou, C Triantos - Biomedicines, 2024 - mdpi.com
The human reward network consists of interconnected brain regions that process stimuli
associated with satisfaction and modulate pleasure-seeking behaviors. Impairments in …

The effect of glucagon-like peptide 1 receptor agonists on alcohol and tobacco craving among patients with type 2 diabetes mellitus: a cross-sectional, questionnaire …

J Budzyński, D Czarnecki… - Medical Research …, 2024 - journals.viamedica.pl
Introduction: Glucagon-like peptide 1 receptor (GLP-1R) agonists are widely used in therapy
for type 2 diabetes mellitus (DM2) and obesity. There are also increasing amounts of data …

LEAP2, a ghrelin receptor inverse agonist, and its effect on alcohol-related responses in rodents

M Tufvesson-Alm, C Aranäs, SB Sköldheden… - 2024 - researchsquare.com
The underlying neurobiology of alcohol use disorder (AUD) is complex and needs further
unraveling, with one of the key mechanisms being the gut-brain peptide ghrelin and its …

[引用][C] Updates for treatments for youth with type 2 diabetes mellitus and obesity.

M Dever - Journal of Pediatric Nursing, 2024 - europepmc.org
Updates for treatments for youth with type 2 diabetes mellitus and obesity. - Abstract - Europe
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