Reactive oxygen species are produced by all aerobic cells and are widely believed to play a
pivotal role in aging as well as a number of degenerative diseases. The consequences of …

The crystalline lens is a transparent and refractive biconvex structure formed by lens
epithelial cells (LECs) and lens fibers. Lens opacity, also known as cataracts, is the leading …

Background Cataracts are the main cause of reversible blindness worldwide. The ageing of
the lens caused by ultraviolet B (UVB) radiation is mostly related to oxidative stress (OS) …

The human lens grows by a process of epithelial cell division at its equator and the formation
of generations of differentiated fibre cells. Despite the process of continuous remodelling …

Abstract αA-and αB-crystallins are distinct antiapoptotic regulators. Regarding the
antiapoptotic mechanisms, we have recently demonstrated that αB-crystallin interacts with …

The ocular lens is the only organ that does not develop spontaneous tumor. The molecular
mechanism for this phenomenon remains unknown. Through examination of the signaling …

Lens homeostasis and transparency are dependent on the function and intercellular
communication of its epithelia. While the lens epithelium is uniquely equipped with …

Cataract is a leading ocular disease causing global blindness. The mechanism of
cataractogenesis has not been well defined. Here, we demonstrate that the heat shock …

αA-and αB-crystallins are distinct antiapoptotic regulators. Regarding the antiapoptotic
mechanisms, we have previously demonstrated that under staurosporine treatment, HαA …

Age-related cataracts are a leading cause of blindness. Previously, we have demonstrated
the association of the unfolded protein response with various cataractogenic stressors …