The cornea is the clear, outermost portion of the eye composed of three layers: an
epithelium that provides a protective barrier while allowing transmission of light into the eye …

Acute muscle injury and physiological stress from chronic muscle diseases and aging lead
to impairment of skeletal muscle function. This raises the question of whether p53, a cellular …

A key goal of aging research was to understand mechanisms underlying healthy aging and
develop methods to promote the human healthspan. One approach is to identify gene …

Apoptosis is a tightly regulated biological process that plays an important role in
coordinating cellular proliferation and differentiation. The pathological consequences of …

Caloric restriction has been extensively investigated as an intervention that both extends
lifespan and delays age-related disease in mammals. In mice, much interest has centered …

Skeletal muscle atrophy is a serious and highly prevalent condition that remains poorly
understood at the molecular level. Previous work found that skeletal muscle atrophy involves …

Sarcopenia is linked with impaired adaptive responses to exercise in aging skeletal muscle.
The unfolded protein response (UPR) is an important intramyocellular molecular response …

Functional and structural deterioration of muscles is an inevitable consequence of ageing in
a wide variety of animal species. What underlies these changes is a complex network of …

Although the role of p21 Waf1/Cip1 gene expression is well documented in various cell
culture studies, its in vivo roles are poorly understood. To gain further insight into the role of …

Hearing loss is the most common sensory disorder in the elderly population. Overall, 10% of
the population has a hearing loss in the US, and this age-related hearing disorder is …