[HTML][HTML] The stabilization of Arp2/3 complex generated actin filaments
The Arp2/3 complex, which generates both branched but also linear actin filaments via
activation of SPIN90, is evolutionarily conserved in eukaryotes. Several factors regulate the …
activation of SPIN90, is evolutionarily conserved in eukaryotes. Several factors regulate the …
[HTML][HTML] In situ studies of membrane biology by cryo-electron tomography
J Keller, R Fernández-Busnadiego - Current Opinion in Cell Biology, 2024 - Elsevier
Cryo-electron tomography (cryo-ET) allows high resolution 3D imaging of biological
samples in near-native environments. Thus, cryo-ET has become the method of choice to …
samples in near-native environments. Thus, cryo-ET has become the method of choice to …
[HTML][HTML] Branching out in different directions: Emerging cellular functions for the Arp2/3 complex and WASP-family actin nucleation factors
KG Campellone, NM Lebek, VL King - European journal of cell biology, 2023 - Elsevier
The actin cytoskeleton impacts practically every function of a eukaryotic cell. Historically, the
best-characterized cytoskeletal activities are in cell morphogenesis, motility, and division …
best-characterized cytoskeletal activities are in cell morphogenesis, motility, and division …
[HTML][HTML] Inherited ARPC5 mutations cause an actinopathy impairing cell motility and disrupting cytokine signaling
CJ Nunes-Santos, HS Kuehn, B Boast… - Nature …, 2023 - nature.com
We describe the first cases of germline biallelic null mutations in ARPC5, part of the Arp2/3
actin nucleator complex, in two unrelated patients presenting with recurrent and severe …
actin nucleator complex, in two unrelated patients presenting with recurrent and severe …
[HTML][HTML] ARPC5 deficiency leads to severe early-onset systemic inflammation and mortality
E Sindram, A Caballero-Oteyza… - Disease models & …, 2023 - journals.biologists.com
The Arp2/3 complex drives the formation of branched actin networks that are essential for
many cellular processes. In humans, the ARPC5 subunit of the Arp2/3 complex is encoded …
many cellular processes. In humans, the ARPC5 subunit of the Arp2/3 complex is encoded …
ARPC5 isoforms and their regulation by calcium-calmodulin-N-WASP drive distinct Arp2/3-dependent actin remodeling events in CD4 T cells
L Sadhu, N Tsopoulidis, M Hasanuzzaman, V Laketa… - Elife, 2023 - elifesciences.org
CD4 T cell activation induces nuclear and cytoplasmic actin polymerization via the Arp2/3
complex to activate cytokine expression and strengthen T cell receptor (TCR) signaling …
complex to activate cytokine expression and strengthen T cell receptor (TCR) signaling …
CK-666 and CK-869 differentially inhibit Arp2/3 iso-complexes
The inhibitors, CK-666 and CK-869, are widely used to probe the function of Arp2/3 complex
mediated actin nucleation in vitro and in cells. However, in mammals, the Arp2/3 complex …
mediated actin nucleation in vitro and in cells. However, in mammals, the Arp2/3 complex …
[HTML][HTML] Molecular architecture of the actin cytoskeleton: From single cells to whole organisms using cryo-electron tomography
J Schneider, M Jasnin - Current Opinion in Cell Biology, 2024 - Elsevier
Cryo-electron tomography (cryo-ET) has begun to provide intricate views of cellular
architecture at unprecedented resolutions. Considerable efforts are being made to further …
architecture at unprecedented resolutions. Considerable efforts are being made to further …
Cortactin: A major cellular target of viral, protozoal, and fungal pathogens
I Sharafutdinov, B Friedrich, K Rottner… - Molecular …, 2024 - Wiley Online Library
Many viral, protozoal, and fungal pathogens represent major human and animal health
problems due to their great potential of causing infectious diseases. Research on these …
problems due to their great potential of causing infectious diseases. Research on these …
PI 3-Kinase and the Histone Methyl-Transferase KMT2D Collaborate to Induce Arp2/3-Dependent Migration of Mammary Epithelial Cells
KD Rysenkova, J Gaboriaud, AI Fokin, R Toubiana… - Cells, 2024 - mdpi.com
Breast cancer develops upon sequential acquisition of driver mutations in mammary
epithelial cells; however, how these mutations collaborate to transform normal cells remains …
epithelial cells; however, how these mutations collaborate to transform normal cells remains …