Roadmap: proton therapy physics and biology

H Paganetti, C Beltran, S Both, L Dong… - Physics in Medicine …, 2021 - iopscience.iop.org
The treatment of cancer with proton radiation therapy was first suggested in 1946 followed
by the first treatments in the 1950s. As of 2020, almost 200 000 patients have been treated …

Adaptive proton therapy

H Paganetti, P Botas, GC Sharp… - Physics in Medicine & …, 2021 - iopscience.iop.org
Radiation therapy treatments are typically planned based on a single image set, assuming
that the patient's anatomy and its position relative to the delivery system remains constant …

[HTML][HTML] Dose calculation algorithms for external radiation therapy: an overview for practitioners

F De Martino, S Clemente, C Graeff, G Palma, L Cella - Applied sciences, 2021 - mdpi.com
Featured Application Radiation therapy treatment planning. Abstract Radiation therapy (RT)
is a constantly evolving therapeutic technique; improvements are continuously being …

A critical review of LET-based intensity-modulated proton therapy plan evaluation and optimization for head and neck cancer management

W Deng, Y Yang, C Liu, M Bues… - … Journal of Particle …, 2021 - meridian.allenpress.com
In this review article, we review the 3 important aspects of linear-energy-transfer (LET) in
intensity-modulated proton therapy (IMPT) for head and neck (H&N) cancer management …

Clinical validation of a GPU-based Monte Carlo dose engine of a commercial treatment planning system for pencil beam scanning proton therapy

F Fracchiolla, E Engwall, M Janson, F Tamm… - Physica Medica, 2021 - Elsevier
Purpose To perform the validation of the GPU-based (Graphical Processing Unit based)
proton Monte Carlo (MC) dose engine implemented in a commercial TPS (RayStation 10B) …

[HTML][HTML] Fast robust dose calculation on GPU for high-precision 1H, 4He, 12C and 16O ion therapy: the FRoG platform

S Mein, K Choi, B Kopp, T Tessonnier, J Bauer… - Scientific reports, 2018 - nature.com
Radiotherapy with protons and heavier ions landmarks a novel era in the field of high-
precision cancer therapy. To identify patients most benefiting from this technologically …

Integrating an open source Monte Carlo code “MCsquare” for clinical use in intensity‐modulated proton therapy

W Deng, JE Younkin, K Souris, S Huang… - Medical …, 2020 - Wiley Online Library
Purpose To commission an open source Monte Carlo (MC) dose engine,“MCsquare” for a
synchrotron‐based proton machine, integrate it into our in‐house C++‐based I/O user …

[HTML][HTML] Challenges in Monte Carlo simulations as clinical and research tool in particle therapy: a review

S Muraro, G Battistoni, AC Kraan - Frontiers in Physics, 2020 - frontiersin.org
The use and interest in Monte Carlo (MC) techniques in the field of medical physics have
been rapidly increasing in the past years. This is the case especially in particle therapy …

[HTML][HTML] Clinical implementations of 4D pencil beam scanned particle therapy: report on the 4D treatment planning workshop 2016 and 2017

P Trnková, B Knäusl, O Actis, C Bert, AK Biegun… - Physica Medica, 2018 - Elsevier
Abstract In 2016 and 2017, the 8th and 9th 4D treatment planning workshop took place in
Groningen (the Netherlands) and Vienna (Austria), respectively. This annual workshop …

[HTML][HTML] Development and benchmarking of a Monte Carlo dose engine for proton radiation therapy

P Lysakovski, A Ferrari, T Tessonnier, J Besuglow… - Frontiers in …, 2021 - frontiersin.org
Dose calculation algorithms based on Monte Carlo (MC) simulations play a crucial role in
radiotherapy. Here, the development and benchmarking of a novel MC dose engine …