The adventitia, the outer layer of the blood vessel wall, may be the most complex layer of the
wall and may be the master regulator of wall physiology and pathobiology. This review …

The last 20–25 years have seen an explosion of interest in the role of NADPH oxidase
(NOX) in cardiovascular function and disease. In vascular smooth muscle and endothelium …

Arteriosclerosis causes significant morbidity and mortality worldwide. Central to this process
is the development of subclinical non-atherosclerotic intimal lesions before the appearance …

Abstract Significance: NADPH oxidases (Noxs), of which there are seven isoforms (Nox1–5,
Duox1/Duox2), are professional oxidases functioning as reactive oxygen species (ROS) …

Hydrogen peroxide is an aerobic metabolite playing a central role in redox signaling and
oxidative stress. H 2 O 2 could activate redox sensitive transcription factors, such as Nrf2, AP …

Pulmonary hypertension (PH) is a chronic and fatal disease, for which new therapeutic
drugs and approaches are needed urgently. Baicalein and baicalin, the active compounds …

Background: Alzheimer's disease (AD) is the most common neurodegenerative condition
worldwide, with amyloid ß (Aβ) fibrils presenting as its main pathological feature. This study …

Background Acute lung injury (ALI) is a common complication following severe burns. The
underlying mechanisms of ALI are incompletely understood; thus, available treatments are …

Nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) is a subtype of the NOX
family, which is mainly expressed in the pulmonary vasculature and pulmonary endothelial …

Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have been
evaluated in many studies as promising therapeutic agents for pulmonary hypertension …