Cancer the 'RBP'eutics–RNA-binding proteins as therapeutic targets for cancer
RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …
including splicing, cleavage and polyadenylation, transport, translation and degradation of …
Next-generation immuno-oncology agents: current momentum shifts in cancer immunotherapy
C Pan, H Liu, E Robins, W Song, D Liu, Z Li… - Journal of hematology & …, 2020 - Springer
Cancer immunotherapy has reached a critical point, now that immune checkpoint inhibitors
and two CAR-T products have received market approval in treating 16 types of cancers and …
and two CAR-T products have received market approval in treating 16 types of cancers and …
PCBP1 regulates the transcription and alternative splicing of metastasis‑related genes and pathways in hepatocellular carcinoma
S Huang, K Luo, L Jiang, XD Zhang, YH Lv, RF Li - Scientific reports, 2021 - nature.com
PCBP1 is a multifunctional RNA-binding protein (RBP) expressed in most human cells and
is involved in posttranscriptional gene regulation. PCBP1 regulates the alternative splicing …
is involved in posttranscriptional gene regulation. PCBP1 regulates the alternative splicing …
RNA splicing regulators play critical roles in neurogenesis
Alternative RNA splicing increases transcript diversity in different cell types and under
varying conditions. It is executed with the help of RNA splicing regulators (RSRs), which are …
varying conditions. It is executed with the help of RNA splicing regulators (RSRs), which are …
Borax regulates iron chaperone‐and autophagy‐mediated ferroptosis pathway in glioblastoma cells
C Hacioglu, F Kar, F Davran… - Environmental …, 2023 - Wiley Online Library
Glioblastoma (GBM) is classified as a stage‐IV glioma. Unfortunately, there are currently no
curative treatments for GBM. Poly (rC)‐binding protein 1 (PCBP1) is a cytosolic iron …
curative treatments for GBM. Poly (rC)‐binding protein 1 (PCBP1) is a cytosolic iron …
Discovery of tetrahydroisoquinolineindole derivatives as first dual PRMT5 inhibitors/hnRNP E1 upregulators: design, synthesis and biological evaluation
WH Chu, N Yang, JH Zhang, Y Li, JL Song… - European Journal of …, 2023 - Elsevier
Abstract Protein arginine methyltransferase 5 (PRMT5) is an epigenetics related enzyme
that has been validated as an important therapeutic target for treating various types of …
that has been validated as an important therapeutic target for treating various types of …
easyCLIP analysis of RNA-protein interactions incorporating absolute quantification
Quantitative criteria to identify proteins as RNA-binding proteins (RBPs) are presently
lacking, as are criteria to define RBP target RNAs. Here, we develop an ultraviolet (UV) …
lacking, as are criteria to define RBP target RNAs. Here, we develop an ultraviolet (UV) …
EGCG‐LYS Fibrils‐Mediated CircMAP2K2 Silencing Decreases the Proliferation and Metastasis Ability of Gastric Cancer Cells in Vitro and in Vivo
J Dong, Z Zheng, M Zhou, Y Wang, J Chen… - Advanced …, 2023 - Wiley Online Library
Aberrant expression of circular RNAs (circRNAs) has been reported to play an important
biological regulatory role in gastric cancer (GC). For the purpose of silencing cancer‐related …
biological regulatory role in gastric cancer (GC). For the purpose of silencing cancer‐related …
[HTML][HTML] Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer
W Kong, G Yin, S Zheng, X Liu, A Zhu, P Yu, J Zhang… - Genes & …, 2022 - Elsevier
Gastric cancer is one of the first malignant cancers in the world and a large number of
people die every year due to this disease. Many genetic and epigenetic risk factors have …
people die every year due to this disease. Many genetic and epigenetic risk factors have …
RNA binding protein PCBP1 is an intracellular immune checkpoint for shaping T cell responses in cancer immunity
EA Ansa-Addo, HC Huang, B Riesenberg… - Science …, 2020 - science.org
Distinct lineages of T cells can act in response to various environmental cues to either drive
or restrict immune-mediated pathology. Here, we identify the RNA binding protein, poly (C) …
or restrict immune-mediated pathology. Here, we identify the RNA binding protein, poly (C) …