Cancer the 'RBP'eutics–RNA-binding proteins as therapeutic targets for cancer

S Mohibi, X Chen, J Zhang - Pharmacology & therapeutics, 2019 - Elsevier
RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …

Next-generation immuno-oncology agents: current momentum shifts in cancer immunotherapy

C Pan, H Liu, E Robins, W Song, D Liu, Z Li… - Journal of hematology & …, 2020 - Springer
Cancer immunotherapy has reached a critical point, now that immune checkpoint inhibitors
and two CAR-T products have received market approval in treating 16 types of cancers and …

PCBP1 regulates the transcription and alternative splicing of metastasis‑related genes and pathways in hepatocellular carcinoma

S Huang, K Luo, L Jiang, XD Zhang, YH Lv, RF Li - Scientific reports, 2021 - nature.com
PCBP1 is a multifunctional RNA-binding protein (RBP) expressed in most human cells and
is involved in posttranscriptional gene regulation. PCBP1 regulates the alternative splicing …

RNA splicing regulators play critical roles in neurogenesis

E Fisher, J Feng - Wiley Interdisciplinary Reviews: RNA, 2022 - Wiley Online Library
Alternative RNA splicing increases transcript diversity in different cell types and under
varying conditions. It is executed with the help of RNA splicing regulators (RSRs), which are …

Borax regulates iron chaperone‐and autophagy‐mediated ferroptosis pathway in glioblastoma cells

C Hacioglu, F Kar, F Davran… - Environmental …, 2023 - Wiley Online Library
Glioblastoma (GBM) is classified as a stage‐IV glioma. Unfortunately, there are currently no
curative treatments for GBM. Poly (rC)‐binding protein 1 (PCBP1) is a cytosolic iron …

Discovery of tetrahydroisoquinolineindole derivatives as first dual PRMT5 inhibitors/hnRNP E1 upregulators: design, synthesis and biological evaluation

WH Chu, N Yang, JH Zhang, Y Li, JL Song… - European Journal of …, 2023 - Elsevier
Abstract Protein arginine methyltransferase 5 (PRMT5) is an epigenetics related enzyme
that has been validated as an important therapeutic target for treating various types of …

easyCLIP analysis of RNA-protein interactions incorporating absolute quantification

DF Porter, W Miao, X Yang, GA Goda, AL Ji… - Nature …, 2021 - nature.com
Quantitative criteria to identify proteins as RNA-binding proteins (RBPs) are presently
lacking, as are criteria to define RBP target RNAs. Here, we develop an ultraviolet (UV) …

EGCG‐LYS Fibrils‐Mediated CircMAP2K2 Silencing Decreases the Proliferation and Metastasis Ability of Gastric Cancer Cells in Vitro and in Vivo

J Dong, Z Zheng, M Zhou, Y Wang, J Chen… - Advanced …, 2023 - Wiley Online Library
Aberrant expression of circular RNAs (circRNAs) has been reported to play an important
biological regulatory role in gastric cancer (GC). For the purpose of silencing cancer‐related …

[HTML][HTML] Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer

W Kong, G Yin, S Zheng, X Liu, A Zhu, P Yu, J Zhang… - Genes & …, 2022 - Elsevier
Gastric cancer is one of the first malignant cancers in the world and a large number of
people die every year due to this disease. Many genetic and epigenetic risk factors have …

RNA binding protein PCBP1 is an intracellular immune checkpoint for shaping T cell responses in cancer immunity

EA Ansa-Addo, HC Huang, B Riesenberg… - Science …, 2020 - science.org
Distinct lineages of T cells can act in response to various environmental cues to either drive
or restrict immune-mediated pathology. Here, we identify the RNA binding protein, poly (C) …