Materials and methods Coronaviruses are classified into four genera: α, β, γ, and δ. All
seven coronaviruses known to cause respiratory infections in humans fall into the α or β …

已知人类致病性冠状病毒可分为7 种, 即HCoV-229E, HCoV-OC43, HCoV-HKU1, HCoV-
NL63, SARS-CoV, MERS-CoV 和SARS-CoV-2. 其中, 后3 种冠状病毒分别引起的严重急性 …

Pharmaceutical wastewater contamination via azithromycin antibiotic and the continuous
emergence of some strains of bacteria, cancer, and the Covid‑19 virus. Azithromycin …

To initiate SARS-CoV-2 infection, the Receptor Binding Domain (RBD) on the viral spike
protein must first bind to the host receptor ACE2 protein on pulmonary and other ACE2 …

Broadly effective antiviral therapies must be developed to be ready for clinical trials, which
should begin soon after the emergence of new life-threatening viruses. Here, we pave the …

We have observed two cases in which ciclesonide, an inhaled steroid drug for bronchial
asthma, had a possibly useful effect on novel coronavirus disease (coronavirus disease …

An increasing body of literature describes the role of host factors in COVID-19 pathogenesis.
There is a need to combine diverse, multi-omic data in order to evaluate and substantiate …

Complex mixtures containing natural products are still an interesting source of novel drug
candidates. High content screening (HCS) is a popular tool to screen for such. In particular …

Small animal models have been a challenge for the study of SARS-CoV-2 transmission, with
most investigators using golden hamsters or ferrets. Mice have the advantages of low cost …

Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) caused a global
healthcare crisis due to COVID-19 pandemic. In absence of efficacious antiviral drugs …