The parasites Leishmania spp., Trypanosoma brucei, and Trypanosoma cruzi are the
trypanosomatid protozoa that cause the deadly human diseases leishmaniasis, African …

Epigenetic regulation is important in many facets of eukaryotic biology. Recent work has
suggested that the basic mechanisms underlying epigenetic regulation extend to eukaryotic …

The present review addresses basic aspects of the biology of the pathogenic protozoa
Trypanosoma cruzi and some comparative information of Trypanosoma brucei. Like …

Trypanosomes are ancient eukaryotic parasites in which the protein-coding genes,
organized in large polycistronic clusters on both strands, are transcribed from as yet …

Protozoan parasites continue to cause a significant health and economic burden worldwide.
As infectious organisms, they pose unique and difficult challenges due to a level of …

Histone variants play a crucial role in chromatin structure organization and gene expression.
Trypanosomatids have an unusual H2B variant (H2B. V) that is known to dimerize with the …

Several biological processes in Trypanosoma brucei are affected by chromatin structure,
including gene expression, cell cycle regulation, and life-cycle stage differentiation. In …

Leishmania spp., Trypanosoma cruzi, and Trypanosoma brucei are protozoan parasites that
cause a spectrum of fatal human diseases around the world. Recent completion of the …

Trypanosome histone N-terminal sequences are very divergent from the other eukaryotes,
although they are still decorated by post-translational modifications (PTMs). Here, we used a …

Protozoa constitute the earliest branch of the eukaryotic lineage, and several groups of
protozoans are serious parasites of humans and other animals. Better understanding of …