Epigenetic modification in diabetic kidney disease

Z Liu, J Liu, W Wang, X An, L Luo, D Yu… - Frontiers in …, 2023 - frontiersin.org
Diabetic kidney disease (DKD) is a common microangiopathy in diabetic patients and the
main cause of death in diabetic patients. The main manifestations of DKD are proteinuria …

Long Noncoding RNA SOX2‐OT: Regulations, Functions, and Roles on Mental Illnesses, Cancers, and Diabetic Complications

PY Li, P Wang, SG Gao… - BioMed research …, 2020 - Wiley Online Library
SRY‐box transcription factor 2 (SOX2) overlapping transcript (SOX2‐OT) is an evolutionarily
conserved long noncoding RNA. Its intronic region contains the SOX2 gene, the major …

lncRNA GAS5/miR-452-5p reduces oxidative stress and pyroptosis of high-glucose-stimulated renal tubular cells

C Xie, W Wu, A Tang, N Luo, Y Tan - Diabetes, metabolic syndrome …, 2019 - Taylor & Francis
Background Diabetic nephropathy (DN) is the leading cause of end-stage renal failure
worldwide. lncRNAs are demonstrated to improve the DN by changing the expression of …

LncRNA SOX2OT alleviates mesangial cell proliferation and fibrosis in diabetic nephropathy via Akt/mTOR-mediated autophagy

K Chen, B Yu, J Liao - Molecular medicine, 2021 - Springer
Background Accumulating evidences have demonstrated that long non-coding RNAs
(lncRNAs) are involved in the pathophysiology of diabetic nephropathy (DN). lncRNA …

Atorvastatin regulates MALAT1/miR-200c/NRF2 activity to protect against podocyte pyroptosis induced by high glucose

Y Zuo, L Chen, X He, Z Ye, L Li, Z Liu… - … Syndrome and Obesity, 2021 - Taylor & Francis
Background Diabetic nephropathy (DN) is one of the main complications of diabetes mellitus
(DM), which leads to the long-term loss of kidney functions. Long noncoding RNAs …

Circ ASAP2 decreased inflammation and ferroptosis in diabetic nephropathy through SOX2/SLC7A11 by miR-770-5p

Q Li, X Meng, Q Hua - Acta Diabetologica, 2023 - Springer
Aims Diabetes nephropathy (DN) is one of the major complications in diabetes. With the
improvement of people's living standards in China in recent years, the incidence of diabetes …

Relationship between Biochemical Pathways and Non-Coding RNAs Involved in the Progression of Diabetic Retinopathy

M Mrowicka, J Mrowicki, I Majsterek - Journal of Clinical Medicine, 2024 - mdpi.com
Diabetic retinopathy (DR) is a progressive blinding disease, which affects the vision and
quality of life of patients, and it severely impacts the society. This complication, caused by …

Analysis of circulating lncRNA expression profiles in patients with diabetes mellitus and diabetic nephropathy: Differential expression profile of circulating lncRNA

Y Yang, X Lv, Q Fan, X Wang, L Xu, X Lu… - Clinical …, 2019 - search.proquest.com
Background: In order to elucidate the epigenetic mechanism and explore new biomarkers
for diabetes and diabetic nephropathy, circulating lncRNA and mRNA expression profiles of …

LncRNA SOX2OT alleviates the high glucose-induced podocytes injury through autophagy induction by the miR-9/SIRT1 axis

Y Zhang, B Chang, J Zhang, X Wu - Experimental and molecular pathology, 2019 - Elsevier
Objectives Podocytes injury is a major contributor to the progression of diabetic nephropathy
(DN). This study aims to investigate the role of long non-coding RNA SOX2OT in the high …

Long non-coding RNA CASC2 restrains high glucose-induced proliferation, inflammation and fibrosis in human glomerular mesangial cells through mediating miR …

D Zhu, X Wu, Q Xue - Diabetology & Metabolic Syndrome, 2021 - Springer
Background Diabetic nephropathy (DN) is a common complication of diabetes. Long non-
coding RNA (lncRNA) cancer susceptibility candidate 2 (CASC2) is reported to exert a …