To search for unique mutations in the apolipoprotein B (apoB) gene that disrupt the binding
of LDL to its receptor and cause hypercholesterolemia, we examined more than 800 patients …

Familial combined hyperlipidemia (FCH) is a heritable lipid disorder that is associated with
an increased risk of premature cardiovascular disease. An elevated plasma apolipoprotein …

OBJECTIVE: Twin studies are used extensively to decompose the variance of a trait, mainly
to estimate the heritability of the trait. A second purpose of such studies is to estimate to what …

INTRODUCTION: The acute phase reactant fibrinogen plays a critical role in the coagulation
system and inflammation. Recently several polymorphisms have been described regulating …

It has been suggested that genetic factors control blood pressure level at all ages. However,
the evidence is limited because of the composite nature of blood pressure and the …

Elevated plasma levels of apolipoproteins A1 (apoA1) and B (apoB) are important protective
factors and risk factors, respectively, for atherosclerosis and coronary heart disease. It is well …

Complex segregation analyses of apolipoproteins (apo) A-1 and B-100 were performed in a
sample of 520 individuals from 99 white families who participated in the HERITAGE Family …

Multivariate genetic analysis, implemented in the statistical package for pedigree analysis,
FISHER, was carried out on a large sample of Israeli pedigrees to evaluate heritability and …

Elevated plasma levels of apolipoprotein A1 (APO‐A1) and high‐density lipoprotein
cholesterol (HDL‐C) are important protective factors for atherosclerosis and coronary heart …

Complex segregation analyses of apolipoproteins (apo) A-1 and B-100 were performed in a
sample of 520 individuals from 99 white families who participated in the HERITAGE Family …