Human herpesviruses 6A and 6B in brain diseases: association versus causation

AL Komaroff, PE Pellett, S Jacobson - Clinical microbiology …, 2020 - Am Soc Microbiol
SUMMARY Human herpesvirus 6A (HHV-6A) and human herpesvirus 6B (HHV-6B),
collectively termed HHV-6A/B, are neurotropic viruses that permanently infect most humans …

Molecular mechanisms in the genesis of seizures and epilepsy associated with viral infection

W Löscher, CL Howe - Frontiers in molecular neuroscience, 2022 - frontiersin.org
Seizures are a common presenting symptom during viral infections of the central nervous
system (CNS) and can occur during the initial phase of infection (“early” or acute …

Herpesvirus and neurological manifestations in patients with severe coronavirus disease

VCS Carneiro, SV Alves-Leon, DJS Sarmento… - Virology journal, 2022 - Springer
Background Certain clinical manifestations of coronavirus disease (COVID-19) mimic those
associated with human herpesvirus (HHV) infection. In this study, we estimated the …

Family Herpesviridae and neuroinfections: current status and research in progress

VCS Carneiro, JG Pereira, VS de Paula - Memórias do Instituto …, 2022 - SciELO Brasil
This article addresses the relationship between human herpesviruses (HHVs) and
neuroinfections. Alphaherpesviruses, betaherpesviruses and gammaherpesviruses are …

The contribution of microglia and brain-infiltrating macrophages to the pathogenesis of neuroinflammatory and neurodegenerative diseases during TMEV infection of …

AB DePaula-Silva - Viruses, 2024 - mdpi.com
The infection of the central nervous system (CNS) with neurotropic viruses induces
neuroinflammation and is associated with the development of neuroinflammatory and …

The Role of Human Herpesvirus 6 Infection in Alzheimer's Disease Pathogenicity—A Theoretical Mosaic

C Romanescu, TG Schreiner, I Mukovozov - Journal of Clinical Medicine, 2022 - mdpi.com
Alzheimer's disease (AD), a neurodegenerative disorder generally affecting older adults, is
the most common form of dementia worldwide. The disease is marked by severe cognitive …

Differential impacts of HHV-6A versus HHV-6B infection in differentiated human neural stem cells

E Bahramian, M Furr, JT Wu, RM Ceballos - Frontiers in Immunology, 2022 - frontiersin.org
Within the family Herpesviridae, sub-family β-herpesvirinae, and genus Roseolovirus, there
are only three human herpesviruses that have been described: HHV-6A, HHV-6B, and HHV …

Human herpesvirus 6A U4 inhibits proteasomal degradation of the amyloid precursor protein

T Tang, J Jia, E Garbarino, L Chen, J Ma, P Li… - Journal of …, 2022 - Am Soc Microbiol
ABSTRACT Human herpesvirus 6 (HHV-6) belongs to the betaherpesvirus subfamily and is
divided into two distinct species, HHV-6A and HHV-6B. HHV-6 can infect nerve cells and is …

Microglia and infiltrating macrophages in ictogenesis and epileptogenesis

S Bröer, A Pauletti - Frontiers in Molecular Neuroscience, 2024 - frontiersin.org
Phagocytes maintain homeostasis in a healthy brain. Upon injury, they are essential for
repairing damaged tissue, recruiting other immune cells, and releasing cytokines as the first …

Inflammation unleashed in viral-induced epileptogenesis

AB DePaula-Silva, LA Bell, GJ Wallis… - Epilepsy …, 2021 - journals.sagepub.com
Viral infection of the central nervous system increasingly places people at risk of developing
life-threatening and treatment-resistant acute and chronic seizures (epilepsy). The …